4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE

4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE - Names and Identifiers

Name	4-chloro-7-methylthieno[3,2-d]pyrimidine
Synonyms	4-Chloro-7-Methylthieno[3... 7-CHLORO-3-METHYLTHIENO(3,2-D)PYRIMIDINE 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE 4-Chloro-7-methylthieno[2,3-d]pyrimidine 4-chloro-7-methylthieno[3,2-d]pyrimidine Thieno[3,2-d]pyrimidine,4-chloro-7-methyl-
CAS	175137-21-0
InChI	InChI=1/C7H5ClN2S/c1-4-2-11-6-5(4)9-3-10-7(6)8/h2-3H,1H3

4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE - Physico-chemical Properties

Molecular Formula	C7H5ClN2S
Molar Mass	184.65
Density	1.445±0.06 g/cm3(Predicted)
Melting Point	124 °C
Boling Point	301.3±37.0 °C(Predicted)
Flash Point	136°C
Vapor Presure	0.0019mmHg at 25°C
pKa	0.78±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.682

4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36 - Irritating to the eyes
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Hazard Note	Irritant

4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE - Reference Information

introduction

4-chloro-7-methylthieno [3,2-D] pyrimidine belongs to thienopyrimidine derivatives, which are fused heterocyclic compounds with good biological activity, especially in medicine.

preparation

7-methylthieno [3,2-D] pyrimidine -4(3H)-one and phosphorus oxychloride are dissolved in acetonitrile solution, the temperature is raised from 65 ℃(30~60 min) to 85 ℃, the reflux reaction is 1
~ 2
h, and the reaction process is detected by thin layer chromatography, after the reaction, the heating was stopped, the reaction system was cooled to room temperature, the reaction solution was extracted with ammonia and ethyl acetate, the organic phase was concentrated to obtain the crude product, and the 4-chloro-7-methylthieno [3,2-D] pyrimidine was obtained by column chromatography purification.

Last Update：2024-04-09 02:00:07