Molecular Formula | C6H13Cl2N |
Molar Mass | 170.08 |
Melting Point | 158-162°C(lit.) |
Boling Point | 47-48 °C(Press: 10 Torr) |
Flash Point | 54°C |
Water Solubility | very faint turbidity |
Solubility | DMSO, Methanol, Water |
Vapor Presure | 1.85mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
BRN | 3677071 |
Storage Condition | -20°C Freezer |
Sensitive | Hygroscopic |
MDL | MFCD00012834 |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
HS Code | 29333999 |
Hazard Note | Irritant |
use | pharmaceutical intermediates. |
production method | methylamine is used as raw material, and is obtained by addition, cyclization, hydrolysis elimination, catalytic hydrogenation and chlorination. 1. The addition of methylamine reacts with methyl acrylate to obtain N-methyl-N-,N-bis (β-methoxycarbonyl ethyl) amine (adduct). 2. The cyclization reacts N-methyl-N,N-bis (β-methoxycarbonyl ethyl) amine (adduct) with sodium methoxide to form 1-methyl-3-methoxycarbonyl Piperidone-[4]. 3. Hydrolysis and elimination will produce 1-methyl -3-methoxycarbonyl piperidone-[4] reacts with concentrated hydrochloric acid to obtain 1-methyl -4-piperidone hydrochloride. 4. Catalytic hydrogenation Hydrogenates the above hydrochloride at room temperature. 5. The hydrogenation product is reacted with thionyl chloride to obtain 4-chloro-1-methylpiperidine. |