Molecular Formula | C10H13Cl2NO2 |
Molar Mass | 250.12 |
Melting Point | 186-189°C(lit.) |
Boling Point | 296.3℃ at 760 mmHg |
Appearance | White powder |
Storage Condition | -20°C |
MDL | MFCD00012530 |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | AY4452100 |
HS Code | 29224999 |
Biological activity | PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is a reversible tryptophan hydroxylase (tryptophan hydroxylase) inhibitor is an inhibitor of serotonin (5-HT) synthesis. PCPA methyl ester hydrochloride can cross the blood-brain barrier and reduce the central utilization rate of 5-HT. |
Animal Model: | C57BL/6 elite male mice (3 months old) |
Dosage: | 500 mg/kg per day for the first 2 days and 250 mg/kg for the rest of the treatment |
Administration: | Oral administration; daily; for 8 weeks |
Result: | Serotonin levels were significantly decreased in both hippocampus and cortex. |
use | tryptophan hydroxylase inhibitor. Crossing the blood-brain barrier is better than P-chlorphenylalanine. |