Molecular Formula | C6H4Cl2O2S |
Molar Mass | 211.07 |
Density | 1.5075 (estimate) |
Melting Point | 50-52 °C (lit.) |
Boling Point | 141 °C/15 mmHg (lit.) |
Flash Point | 226°F |
Water Solubility | INSOLUBLE |
Solubility | soluble in Toluene |
Vapor Presure | 0.00995mmHg at 25°C |
Appearance | White crystal |
Color | Clear |
BRN | 511583 |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Sensitive | Moisture Sensitive |
Refractive Index | 1.569 |
MDL | MFCD00007439 |
Physical and Chemical Properties | Character: White prismatic crystals. melting point 53 ℃ boiling point 141 ℃ solubility soluble in ethanol, insoluble in water. |
Use | The product is mainly used in medicine, engineering plastics, pesticide intermediates and organic synthesis of raw materials for the preparation of chlorobenzene sulfonamide. For the production of pesticide acaricide mite egg Ester, medicine telden, etc. |
Hazard Symbols | C - Corrosive![]() |
Risk Codes | R34 - Causes burns R37 - Irritating to the respiratory system |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 3261 8/PG 2 |
WGK Germany | 2 |
RTECS | DB8925000 |
FLUKA BRAND F CODES | 21 |
TSCA | Yes |
HS Code | 29049020 |
Hazard Note | Corrosive |
Hazard Class | 8 |
Packing Group | II |
White rhomboid crystals. Melting point 53 °c. Boiling point 141 C (2kPa). Soluble in ethanol, insoluble in water. Decomposition in water.
from the reaction of chlorobenzene and chlorosulfonic acid. Chlorosulfonic acid and sulfuric acid were cooled to below 20 ℃, Chlorobenzene was added with strong stirring, reacted at 23~25 ℃ for 2~3H, then heated to 60 ℃, maintained for 2H, cooled, filtered, the finished product was obtained after washing.
pesticides, engineering plastics, pharmaceutical intermediates, can be used for the manufacture of pesticide acaricides, pharmaceutical tyerden.
toxic. Iron drum packaging and storage in a cool, dry, ventilated place.
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Introduction | 4-chlorobenzenesulfonyl chloride is a white prismatic crystal, which is an intermediate in the synthesis of pharmaceuticals. There are many traditional production processes for the synthesis of p-chlorobenzenesulfonyl chloride, and the excessive chlorosulfonic acid method and sulfur trioxide method are commonly used in industrial production at home and abroad. |
Application | 4-chlorobenzenesulfonyl chloride belongs to acid halide compounds, can be used as pharmaceutical intermediates, mainly used in the production of drugs such as Theil. |
Application | used as an intermediate of medicine and pesticide p-chlorobenzenesulfonyl chloride is an intermediate of herbicide sulfamethoxazole, it is also an intermediate of acaricide mite egg Ester and medicine telden. This product is mainly used for the preparation of p-chlorobenzene sulfonamide in medicine, engineering plastics, pesticide intermediates and organic synthesis. For the production of pesticide acaricide mite egg Ester, medicine telden, etc. |
production method | 1. P-aminobenzene sulfonic acid method using p-aminobenzene sulfonic acid as raw material, through diazotization, Sandmeyer reaction to generate p-chlorobenzene sulfonic acid, sodium hydroxide was added to generate sodium p-chlorobenzene sulfonate, which was added to chlorosulfonic acid and reacted at 40-60 ℃ for 3.5h, after cooling, it is dropped into ice water, filtered at 150 ° C., washed to ph = 5.5-6 to obtain a product, and purified by recrystallization to obtain a high purity product. Due to the long reaction route and high cost of sulfanilic acid method, there is no production unit in China at present. 2. Chlorobenzene and chlorosulfonic acid method using chlorobenzene and chlorosulfonic acid as raw materials, chlorosulfonic acid and sulfuric acid are cooled to below 20 ℃, chlorobenzene is added under strong stirring, reaction at 23-25 ℃ for 2-3H, temperature rise to 60 ℃, the product is obtained by cooling and filtering, and the product is purified by recrystallization to obtain a high purity product. Raw material consumption quota: chlorosulfonic acid 2200kg/t, chlorobenzene 650kg/t, sulfuric acid 350kg/t. The preparation method is obtained by chlorosulfonation of chlorobenzene. After chlorosulfonic acid and fuming sulfuric acid are mixed and cooled to below 20 ℃, chlorobenzene is added under strong stirring, reaction is carried out at 23~25 ℃ for 2~3 h, and then at 60 ℃ for 2 h, cooling, filter dry, wash to get acidic. In addition, it can also be obtained by reacting p-chlorobenzene sulfonic acid with chlorosulfonic acid at 60 ℃ for 1.5 h. |
category | toxic substances |
toxicity grade | poisoning |
Acute toxicity | oral-rat LD50: 4250 mg/kg; Intraperitoneal-mouse LDL0:250 mg/kg |
stimulation data | Skin-rabbits 20 mg/24 h moderate; eye-rabbit 0.05 mg/24 h severe |
flammability hazard characteristics | toxic sulfur oxide fumes emitted by thermal decomposition |
storage and transportation characteristics | low temperature ventilation and drying |
extinguishing agent | water, carbon dioxide, foam, dry powder |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |