4-Cyanobenzylzinc bromide solution 0.5M in THF
4-Cyanobenzylzinc bromide
CAS: 135579-87-2
Molecular Formula: C8H6BrNZn
4-Cyanobenzylzinc bromide solution 0.5M in THF - Names and Identifiers
4-Cyanobenzylzinc bromide solution 0.5M in THF - Physico-chemical Properties
| Molecular Formula | C8H6BrNZn |
| Molar Mass | 261.43 |
| Density | 0.956g/mLat 25°C |
| Flash Point | 1°F |
| Storage Condition | 2-8°C |
4-Cyanobenzylzinc bromide solution 0.5M in THF - Risk and Safety
| Risk Codes | R19 - May form explosive peroxides R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin. R40 - Limited evidence of a carcinogenic effect R36/37 - Irritating to eyes and respiratory system. R14 - Reacts violently with water R11 - Highly Flammable |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2056 3/PG 2 |
| WGK Germany | 1 |
4-Cyanobenzylzinc bromide solution 0.5M in THF - Introduction
4-Cyanobenzylzinc bromide is an organic zinc reagent with the chemical formula of C8H6BrN2Zn. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-Cyanobenzylzinc bromide is usually a white or slightly yellow solid powder.
-Solubility: It is soluble in organic solvents (such as ether, dimethylformamide and acetone).
-Stability: 4-Cyanobenzylzinc bromide is relatively stable in the air, but a humid environment should be avoided.
Use:
-Organic synthesis reagent: 4-Cyanobenzylzinc bromide can be used as a reagent in organic synthesis reactions, and is often used to construct carbon-carbon bonds and carbon-cyanide bonds.
-Palladium-catalyzed cross-coupling reactions: It can also be used as a reagent in palladium-catalyzed cross-coupling reactions (such as Suzuki reaction and Stille reaction).
Preparation Method:
- 4-Cyanobenzylzinc bromide can be prepared by adding 4-cyanobenzyl bromide to a mixture of zinc oxide and dimethyl zinc bromide.
Safety Information:
- 4-Cyanobenzylzinc bromide is an organometallic reagent. Safety precautions to be paid attention to when using include:
-Avoid contact with skin and eyes, such as contact immediately with plenty of water rinse.
-The operation should be carried out in a well-ventilated laboratory to avoid inhaling its dust or vapor.
-Avoid contact with combustibles to prevent fire or explosion.
-storage should be sealed, away from heat and fire sources, away from humid environment.
-When using and handling the reagent should follow the relevant safety procedures.
Nature:
-Appearance: 4-Cyanobenzylzinc bromide is usually a white or slightly yellow solid powder.
-Solubility: It is soluble in organic solvents (such as ether, dimethylformamide and acetone).
-Stability: 4-Cyanobenzylzinc bromide is relatively stable in the air, but a humid environment should be avoided.
Use:
-Organic synthesis reagent: 4-Cyanobenzylzinc bromide can be used as a reagent in organic synthesis reactions, and is often used to construct carbon-carbon bonds and carbon-cyanide bonds.
-Palladium-catalyzed cross-coupling reactions: It can also be used as a reagent in palladium-catalyzed cross-coupling reactions (such as Suzuki reaction and Stille reaction).
Preparation Method:
- 4-Cyanobenzylzinc bromide can be prepared by adding 4-cyanobenzyl bromide to a mixture of zinc oxide and dimethyl zinc bromide.
Safety Information:
- 4-Cyanobenzylzinc bromide is an organometallic reagent. Safety precautions to be paid attention to when using include:
-Avoid contact with skin and eyes, such as contact immediately with plenty of water rinse.
-The operation should be carried out in a well-ventilated laboratory to avoid inhaling its dust or vapor.
-Avoid contact with combustibles to prevent fire or explosion.
-storage should be sealed, away from heat and fire sources, away from humid environment.
-When using and handling the reagent should follow the relevant safety procedures.
Last Update：2024-04-10 22:29:15
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