4-Cyanophenylboronic Acid Pinacol Ester
4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS: 171364-82-2
Molecular Formula: C13H16BNO2
4-Cyanophenylboronic Acid Pinacol Ester - Names and Identifiers
4-Cyanophenylboronic Acid Pinacol Ester - Physico-chemical Properties
| Molecular Formula | C13H16BNO2 |
| Molar Mass | 229.08 |
| Density | 1.06±0.1 g/cm3(Predicted) |
| Melting Point | 95-99°C(lit.) |
| Boling Point | 345.8±25.0 °C(Predicted) |
| Flash Point | 162.9°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 6.02E-05mmHg at 25°C |
| Appearance | Light yellow to orange or yellowish brown crystalline powder |
| Color | Light yellow to orange or light tan |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.507 |
| MDL | MFCD03093897 |
| Physical and Chemical Properties | Storage Conditions: recigerator (4 ℃) WGK Germany:3 |
4-Cyanophenylboronic Acid Pinacol Ester - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| TSCA | No |
| HS Code | 29319090 |
| Hazard Class | IRRITANT |
4-Cyanophenylboronic Acid Pinacol Ester - Reference Information
| application | 4-(4,4,5,5-tetramethyl -1,3,2-dioxoborb) benzonitrile is an organic intermediate that can be used in suzuki coupling reactions, mainly used in laboratory research and development processes and chemical production processes. |
| preparation | under argon protection, 91.1g(0.5mol) of 4-bromobenzonitrile, 98.4g(1.2mol) of sodium acetate, 800mL of diethylene glycol dimethyl ether and 152.4g(0.6mol) of bis (pinacol) diboron are added in sequence, the reaction temperature is controlled to 140 ℃, and catalyst 1 is added, 1 '-bis (dicyclohexylphosphine) ferrocene palladium chloride 375.5mg(0.5mmol). After 14 hours of reaction, the reaction was completed by high performance liquid chromatography (HPLC). Quenched with 600mL of water, extracted with 300mL of toluene for 3 times, combined with organic phase, dried with anhydrous magnesium sulfate, filtered, and recovered solvent under reduced pressure to obtain brown solid, and distilled with 4L oil pump to obtain 111.4g of 4-(4,4,5,5-tetramethyl -1,3,2-dioxoborb) benzonitrile. Content 99.5%(GC), yield 97.2%, melting point 93.6-94.5 ℃. |
Last Update：2024-04-09 15:16:36
Supplier List
Spot supply
Product Name: 4-Cyanobenzeneboronic acid, pinacol ester Visit Supplier Webpage Request for quotationCAS: 171364-82-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: 4-Cyanobenzeneboronic acid, pinacol ester Visit Supplier Webpage Request for quotationCAS: 171364-82-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History