4-Ethynyl-piperidine-1-carboxylic acid tert-butyl ester
1-Boc-4-ethynylpiperidine
CAS: 287192-97-6
Molecular Formula: C12H19NO2
4-Ethynyl-piperidine-1-carboxylic acid tert-butyl ester - Names and Identifiers
4-Ethynyl-piperidine-1-carboxylic acid tert-butyl ester - Physico-chemical Properties
| Molecular Formula | C12H19NO2 |
| Molar Mass | 209.28 |
| Density | 1.02±0.1 g/cm3(Predicted) |
| Boling Point | 269.6±29.0 °C(Predicted) |
| Flash Point | 116.84°C |
| Vapor Presure | 0.007mmHg at 25°C |
| pKa | -2.20±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.491 |
4-Ethynyl-piperidine-1-carboxylic acid tert-butyl ester - Introduction
1-Boc-4-ethynylpiperidine is a compound with the chemical formula C15H23NO2. It is a solid, soluble in some organic solvents, such as methanol and dichloromethane, but insoluble in water.
1-Boc-4-ethynylpiperidine has a wide range of applications in organic synthesis. It is often used as an intermediate in organic synthesis and can be used in the synthesis of various other organic compounds. In particular, it can be used to synthesize biologically active compounds, drugs and ligands, such as heparin-like polysaccharide anticoagulants and CCK2 blockers. In addition, it can also be used to construct heterocyclic compounds and catalysts for organic synthesis reactions.
The preparation of 1-Boc-4-ethynylpiperidine is usually achieved by esterifying 4-piperidinylmethanol and acetylene nitrile, and then introducing a protecting group (Boc,tert-butoxycarbonyl). The specific synthetic route can be adjusted according to needs and conditions.
Regarding safety information, 1-Boc-4-ethynylpiperidine is relatively stable under normal conditions, but may decompose under high temperature or high-energy reaction conditions and produce toxic gases. Therefore, appropriate protective measures should be taken during operation, such as wearing appropriate personal protective equipment and operating in well-ventilated conditions. In addition, it is also a combustible substance and should be stored in a cool, dry, well-ventilated place, and away from fire and oxidants. When using or handling it, follow the laboratory's safety guidelines and operating procedures.
1-Boc-4-ethynylpiperidine has a wide range of applications in organic synthesis. It is often used as an intermediate in organic synthesis and can be used in the synthesis of various other organic compounds. In particular, it can be used to synthesize biologically active compounds, drugs and ligands, such as heparin-like polysaccharide anticoagulants and CCK2 blockers. In addition, it can also be used to construct heterocyclic compounds and catalysts for organic synthesis reactions.
The preparation of 1-Boc-4-ethynylpiperidine is usually achieved by esterifying 4-piperidinylmethanol and acetylene nitrile, and then introducing a protecting group (Boc,tert-butoxycarbonyl). The specific synthetic route can be adjusted according to needs and conditions.
Regarding safety information, 1-Boc-4-ethynylpiperidine is relatively stable under normal conditions, but may decompose under high temperature or high-energy reaction conditions and produce toxic gases. Therefore, appropriate protective measures should be taken during operation, such as wearing appropriate personal protective equipment and operating in well-ventilated conditions. In addition, it is also a combustible substance and should be stored in a cool, dry, well-ventilated place, and away from fire and oxidants. When using or handling it, follow the laboratory's safety guidelines and operating procedures.
Last Update：2024-04-09 20:52:54
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