4-Formylphenyl methyl sulphone
4-Methylsulfonyl benzaldehyde
CAS: 5398-77-6
Molecular Formula: C8H8O3S
4-Formylphenyl methyl sulphone - Names and Identifiers
| Name | 4-Methylsulfonyl benzaldehyde |
| Synonyms | 4-Mesylbenzaldehyde 4-Methylsulphonyl be P-methylsufonyl benzaldehyde Of thiaMphenicol benzaldehyde 4-Methylsulfonyl benzaldehyde 4-Formylphenyl methyl sulphone 4-Methylsulphonyl Benzaldehyde 4-(METHYLSULFONYL)BENZALDEHYDE Benzaldehyde,4-(Methylsulfonyl)- |
| CAS | 5398-77-6 |
| EINECS | 674-175-2 |
| InChI | InChI=1/C8H8O3S/c1-12(10,11)8-4-2-7(6-9)3-5-8/h2-6H,1H3 |
4-Formylphenyl methyl sulphone - Physico-chemical Properties
| Molecular Formula | C8H8O3S |
| Molar Mass | 184.21 |
| Density | 1.3761 (rough estimate) |
| Melting Point | 155-161 °C |
| Boling Point | 288.16°C (rough estimate) |
| Flash Point | 242.1°C |
| Solubility | Chloroform, Methanol |
| Vapor Presure | 6.35E-06mmHg at 25°C |
| Appearance | Bright brown crystal |
| Color | Light yellow-beige to light brown |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.5151 (estimate) |
| MDL | MFCD00216485 |
| Physical and Chemical Properties | Crystallization (aqueous ethanol). Melting point 158-159 °c. |
| Use | Used as a pharmaceutical Intermediate |
4-Formylphenyl methyl sulphone - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| HS Code | 29130000 |
| Hazard Note | Irritant |
4-Formylphenyl methyl sulphone - Reference Information
| Overview | p-sulfone benzyl fermentation is an important raw material for the synthesis of thiamphenicol. Like chloramphenicol, thiamphenicol is the second generation of broad-spectrum antibacterial drugs. They have the same antibacterial effect and mechanism to inhibit aerobic gram-negative bacteria and gram-positive bacteria, anaerobic bacteria, Streptococcus and Streptococcus, and it has better inhibitory effect on Gram-negative bacteria. But because it rarely binds to proteins in the blood and is not destroyed by the liver, it is higher than chloramphenicol in the urine and bile, and it is a long-acting drug, so the antibacterial effect in the body is stronger than chloramphenicol. In addition, Some bacteria that are resistant to chloramphenicol, thiamphenicol has a better killing effect. In addition, studies have proved that thiamphenicol can also enhance the body's immune ability. A large number of studies have proved that chloramphenicol has toxic effects on bone marrow cells and liver cells of humans and animals, and can cause dose-related possibility of bone marrow suppression, or dose-independent irreversible aplastic anemia, severe gastrointestinal reactions, Double infection, peripheral neuritis, gray baby syndrome, etc. can also cause immunosuppressive reactions and genotoxicity in broilers and mice. In addition, it is also a teratogen. |
| side effects | years of clinical application, it has been found that thiamphenicol also has many side effects. Mainly manifested in two aspects of non-hematological toxicity and hematological toxicity. The former includes gastrointestinal reactions, abdominal bays, nausea, heartburn and vomiting, skin and membrane sweetness, anorexia, showy head disease and polyneuritis; The latter is manifested as a higher incidence of blood system disorders, an increase in serum iron in the early stage, and a slight decrease in the number of white blood cells, hemoglobin, reticulocytes and red blood cells, in severe cases, bone marrow suppression may occur. In addition, thiamphenicol may also cause peripheral neuritis. In addition, in recent years, the widespread use of antibiotics has led to serious drug resistance. Therefore, the research and development of new antibacterial drugs with low toxicity and high efficiency has important practical significance. |
| use | intermediate of thiamphenicol. Used as a pharmaceutical intermediate |
Last Update：2024-04-09 20:52:54
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