4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester
Leonurine hydrochloride
CAS: 24697-74-3
Molecular Formula: C14H21N3O5
4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester - Names and Identifiers
4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester - Physico-chemical Properties
| Molecular Formula | C14H21N3O5 |
| Molar Mass | 311.33 |
| Density | 1.29±0.1 g/cm3(Predicted) |
| Melting Point | 238 °C |
| Boling Point | 496.7±55.0 °C(Predicted) |
| Solubility | Dissolve in cold water, hot water dissolves 1% ~ 2%. |
| Appearance | White crystalline powder |
| Color | white to beige |
| pKa | 8.26±0.25(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| MDL | MFCD09839432 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Motherwort. |
| In vitro study | Leonurine (0, 5, 10, 20, 40, 80 µM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24 h. Leonurine hydrochloride (125, 250, 500 μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20 µM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner. |
| In vivo study | Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model. |
4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29399990 |
4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester - Reference
| Reference Show more | 1. Qin Meirong, Wang Ping, Wang Xiaowei, et al. Effects of leonurine hydrochloride and stachydrine hydrochloride on uterine contraction in vitro in rats [J]. Today's Pharmacy, 2013(07):410-412. 2. Qiu Zhengying, Li Gang, Xin Ruihua, Cui Dongan, Zhang Kai, Wang Lei, Zhang Kang, Li Jianxi. Preparation and Content Determination of Injectable Leonurus Hydrochloride Acupoint Implantation Gel [J]. Journal of traditional Chinese veterinary medicine, 2020,39(05):29-34. 3. Wu, Haichong, et al. "Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis." International immunopharmacology 61 (2018): 156-161.https://doi.org/10.1016/j.intimp. 2018.06.002 4. [IF=3.943] Haichong Wu et al."Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis."Int Immunopharmacol. 2018 Aug;61:156 5. [IF=4.36] Shi-Jie Bi et al."Network pharmacology-based study on immunomodulatory mechanism of danggui-yimucao herb pair for the treatment of RU486-induced abortion."J Ethnopharmacol. 2022 Jan;282:114609 6. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 |
4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester - Reference Information
| plant source: | motherwort |
| biological activity | Leonurine are alkaloids isolated from Herba leonuri and have antioxidant and anti-inflammatory activities. |
| use | motherwort has the functions of promoting blood circulation, removing stasis, regulating menstruation and eliminating water. Used for content determination/identification/pharmacological experiments and other pharmacological effects: 1. The effect on the uterus Leonurus has an exciting effect on the uterus of rabbits, cats, dogs, guinea pigs and other animals 2. The effect on the circulatory system. A small dose of Leonurus has an enhanced contraction effect on the isolated frog heart, and it is inhibited when used in large amounts. This inhibition may be due to the excitation of the vagus nerve endings. |
Last Update：2024-04-09 21:32:04
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Product Name: Leonurine Hydrochloride Visit Supplier Webpage Request for quotationCAS: 24697-74-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Leonurine hydrochloride Visit Supplier Webpage Request for quotationCAS: 24697-74-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Leonurine hydrochloride Visit Supplier Webpage Request for quotationCAS: 24697-74-3
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
WhatsApp: +86 18374838656
Linkedin: +86 18374838656
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