4-Hydroxy-6-chloroquinoline-3-carboxylic acid

4-Hydroxy-6-chloroquinoline-3-carboxylic acid - Names and Identifiers

Name	6-Chloro-4-hydroxyquinoline-3-carboxylic acid
Synonyms	Nsc79880 6-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 6-chloro-4-oxo-1H-quinoline-3-carboxylic acid 6-Chloro-4-hydroxyquinoline-3-carboxylic acid 4-Hydroxy-6-chloroquinoline-3-carboxylic acid 6-chloro-4-hydroxy-3-quinoline carboxylic acid 6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS	35973-14-9
InChI	InChI=1/C10H6ClNO3/c11-5-1-2-8-6(3-5)9(13)7(4-12-8)10(14)15/h1-4H,(H,12,13)(H,14,15)

4-Hydroxy-6-chloroquinoline-3-carboxylic acid - Physico-chemical Properties

Molecular Formula	C10H6ClNO3
Molar Mass	223.61
Density	1.549g/cm³
Boling Point	399.1°C at 760 mmHg
Flash Point	195.2°C
Vapor Presure	4.36E-07mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.648

4-Hydroxy-6-chloroquinoline-3-carboxylic acid - Introduction

Acid is an organic compound with the chemical formula C10H6ClNO3.

Nature:
Acid is a white or almost white crystalline powder with a special smell. It is sparingly soluble in water and soluble in organic solvents such as alcohols and ketones.

Use:
It is used to synthesize organic compounds such as pesticides, drugs and dyes. It is used as an intermediate for antibacterial and antiviral agents in the pharmaceutical field. In addition, it can also be used as a catalyst for organic synthesis reactions.

Preparation Method:
The preparation of the calcium acid can be obtained by chlorination of 4-aminoquinoline. First, 4-aminoquinoline is reacted with chloroacetyl chloride to form 4-amino-6-chloroquinoline. The 4-amino-6-chloroquinoline is then oxidized to 6-chloro-4-hydroxyquinoline by an oxidation reaction under basic conditions. Finally, by the carboxylation reaction of 6-chloro-4-hydroxyquinoline, the pyridine acid was obtained.

Safety Information:
The dust or solution of acid may have an irritating effect on the eyes, skin and respiratory tract. It is necessary to avoid inhaling its dust or solution and avoid contact with the skin and eyes. Wear protective gloves and goggles during use or handling. In the case of accidental contact, immediately flush the affected area with plenty of water and seek medical help. During storage, it should be kept in a dry, sealed and dark place.

Last Update：2024-04-09 21:01:54