4-METHOXY (1H)INDAZOLE
4-methoxy-1H-indazole
CAS: 351210-06-5
Molecular Formula: C8H8N2O
4-METHOXY (1H)INDAZOLE - Names and Identifiers
| Name | 4-methoxy-1H-indazole |
| Synonyms | 4-Methoxy indazole 4-methoxy-1H-indazole 4-METHOXY (1H)INDAZOLE 1H-indazole, 4-methoxy- 1H-Indazole, 4-methoxy- |
| CAS | 351210-06-5 |
| InChI | InChI=1/C8H8N2O/c1-11-8-4-2-3-7-6(8)5-9-10-7/h2-5H,1H3,(H,9,10) |
4-METHOXY (1H)INDAZOLE - Physico-chemical Properties
| Molecular Formula | C8H8N2O |
| Molar Mass | 148.16 |
| Density | 1.244 |
| Melting Point | 117-120 °C |
| Boling Point | 313℃ |
| Flash Point | 115℃ |
| Vapor Presure | 0.000968mmHg at 25°C |
| pKa | 14.29±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.647 |
4-METHOXY (1H)INDAZOLE - Introduction
4-methoxy-1H-indazole is an organic compound with the chemical formula C9H8N2O and the structural formula CH3OC6H4N = CH. The following is a description of the nature, use, preparation and safety information of 4-methody-1H-indazole:
Nature:
-Appearance: 4-methoxy-1H-indazole is a white to pale yellow solid.
-Solubility: It can be dissolved in organic solvents, such as ethanol, dimethylformamide and dichloromethane, but it is insoluble in water.
Use:
-Pharmaceutical field: 4-methoxy-1H-indazole is an important intermediate compound, commonly used in the synthesis of indazole compounds. These compounds have a variety of biological activities and can be used as drugs or biomarkers.
-Research field: It is also commonly used as a catalyst for organic synthesis reactions.
Preparation Method:
- 4-methoxy-1H-indazole can be prepared by reacting aniline with methanol. First, aniline is converted to chloroaniline by a reagent such as thionyl chloride or phosphorus trichloride. The chloroaniline is then reacted with methanol in the presence of a base to give 4-methoxy-1H-indazole.
-Reaction equation:
C6H5NH2 SOCl2 → C6H5NCl
C6H5NCl CH3OH NaOH → CH3OC6H4NH2 NaCl
Safety Information:
- 4-methoxy-1H-indazole has limited toxicity information, but as a chemical substance, appropriate safety measures should be taken.
-Wear appropriate protective equipment, such as lab gloves and goggles, when using or handling the compound.
-It may cause irritation to the eyes, skin and respiratory tract, so contact with it should be avoided during operation.
-When in contact with the compound, immediately rinse the affected area with plenty of water and seek timely medical help. If discomfort occurs after swallowing, inhalation, or skin absorption, seek medical attention immediately.
Nature:
-Appearance: 4-methoxy-1H-indazole is a white to pale yellow solid.
-Solubility: It can be dissolved in organic solvents, such as ethanol, dimethylformamide and dichloromethane, but it is insoluble in water.
Use:
-Pharmaceutical field: 4-methoxy-1H-indazole is an important intermediate compound, commonly used in the synthesis of indazole compounds. These compounds have a variety of biological activities and can be used as drugs or biomarkers.
-Research field: It is also commonly used as a catalyst for organic synthesis reactions.
Preparation Method:
- 4-methoxy-1H-indazole can be prepared by reacting aniline with methanol. First, aniline is converted to chloroaniline by a reagent such as thionyl chloride or phosphorus trichloride. The chloroaniline is then reacted with methanol in the presence of a base to give 4-methoxy-1H-indazole.
-Reaction equation:
C6H5NH2 SOCl2 → C6H5NCl
C6H5NCl CH3OH NaOH → CH3OC6H4NH2 NaCl
Safety Information:
- 4-methoxy-1H-indazole has limited toxicity information, but as a chemical substance, appropriate safety measures should be taken.
-Wear appropriate protective equipment, such as lab gloves and goggles, when using or handling the compound.
-It may cause irritation to the eyes, skin and respiratory tract, so contact with it should be avoided during operation.
-When in contact with the compound, immediately rinse the affected area with plenty of water and seek timely medical help. If discomfort occurs after swallowing, inhalation, or skin absorption, seek medical attention immediately.
Last Update：2024-04-09 21:01:54
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CAS: 351210-06-5
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CAS: 351210-06-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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