4-METHYL-3-(TRIFLUOROMETHYL)BENZOIC ACID
4-Methyl-3-(trifluoromethyl)benzoic acid
CAS: 261952-01-6
Molecular Formula: C9H7F3O2
4-METHYL-3-(TRIFLUOROMETHYL)BENZOIC ACID - Names and Identifiers
4-METHYL-3-(TRIFLUOROMETHYL)BENZOIC ACID - Physico-chemical Properties
| Molecular Formula | C9H7F3O2 |
| Molar Mass | 204.15 |
| Density | 1.345±0.06 g/cm3(Predicted) |
| Melting Point | 182-186°C |
| Boling Point | 268.6±40.0 °C(Predicted) |
| Flash Point | 94.7°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.0573mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| pKa | 3.94±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.463 |
| MDL | MFCD01631592 |
4-METHYL-3-(TRIFLUOROMETHYL)BENZOIC ACID - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S24/25 - Avoid contact with skin and eyes. S37 - Wear suitable gloves. |
| HS Code | 29163100 |
| Hazard Class | IRRITANT |
4-METHYL-3-(TRIFLUOROMETHYL)BENZOIC ACID - Introduction
4-Methyl-3-(trifluoromethyl)benzoic acid, chemical formula C9H7F3O2, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid
-Molecular weight: 214.15g/mol
-Melting Point: 142-145 ° C
-Boiling point: 302 ° C
-Solubility: Soluble in organic solvents such as ethanol, ether and ether, insoluble in water.
-vulnerable to light, heat and moisture, to avoid exposure to light.
Use:
4-Methyl-3-(trifluoromethyl)benzoic acid is mainly used as catalyst and intermediate in organic synthesis:
-Catalyst: It can be used as a ligand of palladium catalyst and play a catalytic role in some chemical reactions.
-Intermediate: It can also be used as an intermediate in organic synthesis for the synthesis of other compounds.
Method:
4-Methyl-3-(trifluoromethyl)benzoic acid is usually synthesized by the following steps:
1. First, methylbenzaldehyde reacts with a trifluoromethyl acylating reagent to generate 3-trifluoromethyl-4-methylbenzaldehyde.
2.3-trifluoromethyl-4-methylbenzaldehyde is then reacted with sodium hydroxide to form sodium 4-Methyl-3-(trifluoromethyl)benzoic acid.
3. Finally, the resulting sodium salt reacts with an acid to produce 4-Methyl-3-(trifluoromethyl)benzoic acid.
Safety Information:
- 4-Methyl-3-(trifluoromethyl)benzoic acid can cause irritation to the eyes, skin and respiratory system.
-When using, pay attention to avoid inhalation, contact with skin and eyes, and wear protective equipment when necessary.
-In case of accidental contact, rinse the affected area with water immediately and seek medical help when needed.
-Store in a dry, cool place, away from fire and oxidizing agents.
Nature:
-Appearance: White crystalline solid
-Molecular weight: 214.15g/mol
-Melting Point: 142-145 ° C
-Boiling point: 302 ° C
-Solubility: Soluble in organic solvents such as ethanol, ether and ether, insoluble in water.
-vulnerable to light, heat and moisture, to avoid exposure to light.
Use:
4-Methyl-3-(trifluoromethyl)benzoic acid is mainly used as catalyst and intermediate in organic synthesis:
-Catalyst: It can be used as a ligand of palladium catalyst and play a catalytic role in some chemical reactions.
-Intermediate: It can also be used as an intermediate in organic synthesis for the synthesis of other compounds.
Method:
4-Methyl-3-(trifluoromethyl)benzoic acid is usually synthesized by the following steps:
1. First, methylbenzaldehyde reacts with a trifluoromethyl acylating reagent to generate 3-trifluoromethyl-4-methylbenzaldehyde.
2.3-trifluoromethyl-4-methylbenzaldehyde is then reacted with sodium hydroxide to form sodium 4-Methyl-3-(trifluoromethyl)benzoic acid.
3. Finally, the resulting sodium salt reacts with an acid to produce 4-Methyl-3-(trifluoromethyl)benzoic acid.
Safety Information:
- 4-Methyl-3-(trifluoromethyl)benzoic acid can cause irritation to the eyes, skin and respiratory system.
-When using, pay attention to avoid inhalation, contact with skin and eyes, and wear protective equipment when necessary.
-In case of accidental contact, rinse the affected area with water immediately and seek medical help when needed.
-Store in a dry, cool place, away from fire and oxidizing agents.
Last Update：2024-04-10 22:29:15
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Product Name: 4-Methyl-3-(trifluoromethyl)benzoic acid Request for quotation
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Mobile: +86-13651600618
QQ: 2850607228
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CAS: 261952-01-6
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