4-N-叔丁氧羰基-哌嗪-2-羧酸

4-N-叔丁氧羰基-哌嗪-2-羧酸 - Names and Identifiers

Name	N-4-Boc-2-piperazinecarboxylic acid
Synonyms	4-BOC- (4-N-BOC)PIPERAZINE(2R) COOH 4-BOCpiperazin-2-carboxylic acid 4-Boc-2-piperazinecarboxylic acid 4-BOC-PIPERAZINE-2-CARBOXYLIC ACID 4-N-Boc-2-piperazinecarboxylic acid N-4-Boc-2-piperazinecarboxylic acid 4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID 4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID (R)-4-Boc-piperazine-2-carboxylid acid 4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID 4-(TERT-BUTOXYLCARBONYL)-PIPERAZINE-2-CARBOXYLIC ACID 4-(2,2-dimethylpropanoyloxy)piperazine-2-carboxylic acid 1,3-PIPERAZINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER 1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 4-Boc-piperazine-2-carboxylic acid,1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester
CAS	128019-59-0
InChI	InChI=1/C10H18N2O4/c1-10(2,3)9(15)16-12-5-4-11-7(6-12)8(13)14/h7,11H,4-6H2,1-3H3,(H,13,14)

4-N-叔丁氧羰基-哌嗪-2-羧酸 - Physico-chemical Properties

Molecular Formula	C10H18N2O4
Molar Mass	230.26
Density	1.193±0.06 g/cm3(Predicted)
Melting Point	231-239 °C
Boling Point	371.8±37.0 °C(Predicted)
Flash Point	174.2°C
Water Solubility	Slightly soluble in water.
Vapor Presure	2.65E-06mmHg at 25°C
Appearance	powder or crystals
pKa	2.20±0.20(Predicted)
Storage Condition	2-8°C(protect from light)
Refractive Index	1.519
MDL	MFCD01076218

4-N-叔丁氧羰基-哌嗪-2-羧酸 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact R36 - Irritating to the eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36/37 - Wear suitable protective clothing and gloves.
WGK Germany	3
HS Code	29335990
Hazard Class	IRRITANT

4-N-叔丁氧羰基-哌嗪-2-羧酸 - Introduction

4-Boc-piperazine-2-carboxylic acid, full name acid, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
4-Boc-piperazine-2-carboxylic acid is a colorless crystal or white solid with good solubility. It is a carboxylic acid compound containing a very stable 4-tert-butoxycarbonyl protecting group. Its chemical structure contains piperazine and pyrimidine rings, and there is a carboxyl group on the pyrimidine ring.

Use:
4-Boc-piperazine-2-carboxylic acid is a commonly used organic synthesis intermediate, which can be used to synthesize various organic compounds. It is often used in the field of drug synthesis as a key raw material for the synthesis of certain drug molecules. In addition, it can also be used in dye synthesis, ligand synthesis and enzymatic research.

Preparation Method:
The preparation method of 4-Boc-piperazine-2-carboxylic acid usually involves the modification of piperazine compounds. A common synthesis method is to react piperazine with the corresponding acid chloride, then use tetra-tert-butyl perpotassium carbonate (TBHP) and osmium tetroxide (OsO4) system for oxidation, and finally through hydrolysis reaction to obtain the target product.

Safety Information:

Last Update：2024-04-09 20:52:54