Name | 4-Oxo-4H-1-benzopyran-2-carboxylic acid |
Synonyms | CHROMOCARB Chromocarb LABOTEST-BB LT00454887 CHROMONE-2-CARBOXYLIC ACID Chromone-2-carboxylic acid 4-oxo-4H-chromene-2-carboxylate 4-oxo-4H-chromene-2-carboxylic acid 4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID 4-OXO-4H-BENZOPYRAN-2-CARBOXYLIC ACID 4-oxo-4h-1-benzopyran-2-carboxylicaci 4-OXO-4H-1-BENZOPYRAN-2-CARBOXYLIC ACID 4-Oxo-4H-1-benzopyran-2-carboxylic acid Chromocarb~4-Oxo-4H-1-benzopyran-2-carboxylic acid |
CAS | 4940-39-0 |
EINECS | 225-583-0 |
InChI | InChI=1/C10H6O4/c11-7-5-9(10(12)13)14-8-4-2-1-3-6(7)8/h1-5H,(H,12,13)/p-1 |
Molecular Formula | C10H6O4 |
Molar Mass | 190.15 |
Density | 1.3366 (rough estimate) |
Melting Point | 260°C (dec.)(lit.) |
Boling Point | 285.64°C (rough estimate) |
Flash Point | 138.9°C |
Water Solubility | sparingly soluble |
Solubility | Soluble in alcohol, water (very slightly), DMSO (38 mg/ml at 25 °C), hot methanol, and |
Vapor Presure | 4.23E-05mmHg at 25°C |
Appearance | Powder |
Color | White to beige |
Merck | 14,2237 |
BRN | 146442 |
pKa | 2.28±0.20(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.5280 (estimate) |
MDL | MFCD00006838 |
Physical and Chemical Properties | Melting point 260°C water-soluble sparingly soluble |
In vivo study | Chromocarb is a vasoprotective agent used to treat venous return disorders and microvascular infections. Oral Chromocarb-treated rats significantly reduced the degradation of the vascular wall by venous collagenase. Chromocarb treatment induced a minor increase in BBB permeability, a shorter recovery time, a lower hydroxyproline level in the cerebrospinal fluid, and a minor decline in collagen content in the basement membrane of brain capillaries. Chromocarbe (50 mg/kg) is more effective than vitamin C in preventing the oxidation of reduced glutathione in the blood. Chromocarbe is the most effective compound to prevent lipid peroxidation (malondialdehyde) of exercise-induced immunosuppression in plasma. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
RTECS | DJ2476000 |
HS Code | 29329990 |
Hazard Note | Irritant |
Toxicity | LD50 intraperitoneal in mouse: 585mg/kg |
Uses | 4-benzopyrone -2-carboxylic acid is a carboxylic acid organic compound and can be used as an intermediate in pharmaceutical synthesis. |
biological activity | Chromocarb is a vascular protective agent. |