4-Picoline-5-boronic acid pinacolate

4-Picoline-5-boronic acid pinacolate - Names and Identifiers

Name	4-methylpyridin-3-ylboronic acid pinacol ester
Synonyms	4-Picoline-5-boronic acid pinacolate 4-Methyl-3-pyridylboronic Acid Pinacol Ester 4-methylpyridin-3-ylboronic acid pinacol ester 4-methylpyridin-3-ylboronic acid Pinacol ester 4-methyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-(4-Methyl-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Pyridine, 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CAS	1171891-31-8

4-Picoline-5-boronic acid pinacolate - Physico-chemical Properties

Molecular Formula	C12H18BNO2
Molar Mass	219.09
Density	1.02±0.1 g/cm3(Predicted)
Melting Point	103-107 °C
Boling Point	324.9±30.0 °C(Predicted)
Appearance	powder to crystal
Color	White to Almost white
pKa	5.89±0.20(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C

4-Picoline-5-boronic acid pinacolate - Introduction

4-methylpyridine-3-boronic acid pinacol ester is an organic compound with the chemical formula C9H13BNO2. It has the following properties:

1. Appearance: 4-methylpyridine-3-boronic acid pinacol ester is colorless or light yellow liquid;
2. Solubility: It is soluble in common organic solvents, such as methanol, ethanol, dimethylformamide, etc;
3. stability: it has good stability at room temperature, but with flammability, should avoid contact with the oxidant and avoid high temperature;
4. density: its density is about 1.09g/cm³.

4-methylpyridine-3-boronic acid pinacol ester is mainly used in the field of organic synthesis and is often used as a catalyst precursor. It can be used as a catalyst for the Revells reaction, for the reduction of alcohols, the hydrogenolysis of ketones and the synthesis of hydrogenated carbonates.

One method of preparing 4-methylpyridine-3-boronic acid pinacol ester is by polycondensation of isopropylaminomethanol and boric acid. Specific reaction conditions and methods can be referred to the relevant literature or patent.

Regarding safety information, 4-methylpyridine-3-boronic acid pinacol ester is an organic compound, and the following safety precautions should be paid attention to during operation:

1. avoid inhalation: it should be operated in a well-ventilated place to avoid inhaling its vapor;
2. avoid skin exposure: protective gloves, goggles and other personal protective equipment should be used when touching;
3. Avoid ingestion: Do not ingest or eat by mistake. If you accidentally ingest, you should seek medical attention as soon as possible;
4. fire prevention measures: flammable, should be away from fire or high temperature, storage should be closed, and away from oxidants.

When using and storing, please refer to the relevant chemical safety technical instructions and follow the safety procedures of the laboratory or production site.

Last Update：2024-04-10 22:29:15