4-Piperidinopiperidine-1-carbonyl chloride
1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE
CAS: 103816-19-9
Molecular Formula: C11H19ClN2O
4-Piperidinopiperidine-1-carbonyl chloride - Names and Identifiers
| Name | 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE |
| Synonyms | Irinotecan Impurity 23 1-CHLOROCARBONYL-4-PIPERIDINOPERIDINE 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE [1,4'-Bipiperidine]-1'-carbonyl chloride 4-Piperidinopiperidine-1-carbonyl chloride forMyl[4-(piperidin-1-yl)piperidin-1-yl]chloranuide |
| CAS | 103816-19-9 |
| EINECS | 682-939-1 |
4-Piperidinopiperidine-1-carbonyl chloride - Physico-chemical Properties
| Molecular Formula | C11H19ClN2O |
| Molar Mass | 230.73 |
| Density | 1.184±0.06 g/cm3(Predicted) |
| Melting Point | 60-64°C |
| Boling Point | 344.5±31.0 °C(Predicted) |
| pKa | 9.19±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
4-Piperidinopiperidine-1-carbonyl chloride - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3261 8 / PGIII |
| WGK Germany | 3 |
4-Piperidinopiperidine-1-carbonyl chloride - Introduction
Nature:
[1,4 '] Bipiperidine -1'-carboxylic acid chloride is a colorless or pale yellow liquid with a pungent odor. It has a high vapor pressure and solubility, and can be dissolved in a variety of organic solvents, such as ethanol, methanol and ether. It is a strongly acidic compound that reacts with bases to produce salts.
Use:
[1,4 '] Bipiperidine -1'-carbonyl chloride is commonly used as an intermediate in organic synthesis. It can be used to synthesize compounds such as pesticides, pharmaceuticals and dyes. In addition, it can also be used for acylation, acyl chlorination and acyl substitution in organic synthesis reactions.
Preparation Method:
The preparation of [1,4 '] bipiperidine -1'-carboxylic acid chloride is generally achieved by acylation of bipiperidine -1-amine. A common method is to use anhydrous formic acid as the acylating agent and to add an acidic catalyst, such as hydrochloric acid or sulfuric acid. The reaction is typically carried out at low temperature to yield [1,4 '] bipiperidine -1'-carboxylic acid chloride.
Safety Information:
Because [1,4 '] bipiperidine -1'-carbonyl chloride is irritating and corrosive, it is necessary to take appropriate safety measures during operation. Wear suitable protective gloves, goggles and protective clothing. Avoid contact with skin, eyes and respiratory tract. Operate in a well-ventilated area and avoid contact with combustibles.
Last Update：2024-04-09 21:04:16
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