4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
sulfisoxazole
CAS: 127-69-5
Molecular Formula: C11H13N3O3S
4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide - Names and Identifiers
| Name | sulfisoxazole |
| Synonyms | SIZ Sulfasol Sulfasan Sulfapolar AKOS B020058 Sulfafurazole Sulfasoxazole sulfisoxazole Sulphafurazole LABOTEST-BB LT00053357 N1-(3,4-dimethylisoxazol-5-yl)sulphanilamide sulfanilamide,n(sup1)-(3,4-dimethyl-5-isoxazolyl) 4-AMINO-N-(3,4-DIMETHYL-5-ISOXAZOLYL)BENZENESULFONAMIDE 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide |
| CAS | 127-69-5 |
| EINECS | 204-858-9 |
| InChI | InChI=1/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3 |
4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide - Physico-chemical Properties
| Molecular Formula | C11H13N3O3S |
| Molar Mass | 267.3 |
| Density | 1.3486 (rough estimate) |
| Melting Point | 195°C |
| Boling Point | 482.2±55.0 °C(Predicted) |
| Flash Point | 245.4°C |
| Solubility | It is dissolved in methanol, slightly dissolved in ethanol, almost insoluble in water, and dissolved in dilute hydrochloric acid or sodium hydroxide solution. |
| Vapor Presure | 1.86E-09mmHg at 25°C |
| Appearance | White to cream powder |
| Color | White to Light Brown |
| Maximum wavelength(λmax) | ['271nm(MeOH)(lit.)'] |
| Merck | 14,8952 |
| BRN | 6737262 |
| pKa | 5.0(at 25℃) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.6630 (estimate) |
| MDL | MFCD00003150 |
| Use | For urinary tract infection, epidemic myelitis, bacillary dysentery, chronic cholecystitis, chronic prostatitis, suppurative tonsillitis |
| In vitro study | The sulfanilamide antibacterial agent sulfisoxazole was found to be a good endothelin receptor antagonist (IC50's of 0.60 microM and 22 microM for the ETA and ETB receptors, respectively) [1]. Sulfisoxazole is used to treat or prevent infections in many different parts of the body. It belongs to the group of medicines known as sulfonamide antibiotics. It works by preventing the growth of bacteria. |
4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| RTECS | WO9100000 |
| HS Code | 29350030 |
| Hazard Class | IRRITANT |
| Toxicity | LD50 orally in mice: 6800 mg/kg (Seki) |
4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide - Reference
| Reference Show more | 1. [IF=7.46] Zijun Xu et al."Machine learning assisted dual-emission fluorescence/colorimetric sensor array detection of multiple antibiotics under stepwise prediction strategy."Sensor Actuat B-Chem. 2022 May;359:131590 2. [IF=4.821] Jin-Ye Lang et al."Preparation of boronate-modified larger mesoporous polymer microspheres with fumed silica nanoparticle and toluene as synergistic porogen for selective separation of sulfonamides."Microchem J. 2022 Apr;175:107193 3. [IF=6.707] Nan Zhang et al."Growth of MOF@COF on corncob as effective adsorbent for enhancing adsorption of sulfonamides and its mechanism."Appl Surf Sci. 2022 Apr;580:152285 4. [IF=4.759] Ji-Cheng Sun et al."Metal-organic framework modified carbon cloth for electric field enhanced thin film microextraction of sulfonamides in animal-derived food."JOURNAL OF CHROMATOGRAPHY A. 2022 May;:463120 |
4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide - Reference Information
| (IARC) carcinogen classification | 3 (Vol. 24, Sup 7) 1987 |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Overview | Sulfamethoxazole is also known as sulfamethoxazole. Sulfamethoxazole is odorless, white crystalline powder, insoluble in water, soluble in hydrochloric acid and alkaline solution, stable in the air. Sulfamethoxazole is a kind of medicine, mainly used to treat urinary tract infection, can also be used for meningitis, bacillary dysentery. |
| Biological activity | Sulfisoxazole (NU-445) is a sulfa antibacterial drug with an oxazole substituent. |
| use | used for urinary tract infection epidemic myelitis, bacillary dysentery, chronic cholecystitis, chronic prostatitis, suppurative tonsillitis, etc. sulfonamides drugs are used to treat infections caused by bacteria. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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