4-chloro-N'-hydroxybenzenecarboximidamide

4-chloro-N'-hydroxybenzenecarboximidamide - Names and Identifiers

Name	4-chloro-N'-hydroxybenzenecarboximidamide
Synonyms	AKOS B022963 BUTTPARK 5212-19 ART-CHEM-BB B022963 4-Chlorobenzamidoxime 4-CHLOROBENZAMIDE OXIME 4-CHLORO-N-HYDROXY-BENZAMIDINE (Z)-4-chloro-N'-hydroxybenzamidine 4-CHLORO-N-HYDROXYBENZENECARBOXIMIDAMIDE 4-CHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE 4-chloro-N'-hydroxybenzenecarboximidamide
CAS	5033-28-3
InChI	InChI=1/C7H7ClN2O/c8-6-3-1-5(2-4-6)7(9)10-11/h1-4,11H,(H2,9,10)

4-chloro-N'-hydroxybenzenecarboximidamide - Physico-chemical Properties

Molecular Formula	C7H7ClN2O
Molar Mass	170.6
Density	1.368g/cm³
Melting Point	131 °C
Boling Point	334.619°C at 760 mmHg
Flash Point	156.172°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0mmHg at 25°C
Appearance	Solid
Color	White to Off-White
Storage Condition	Hygroscopic, -20°C Freezer, Under inert atmosphere
Refractive Index	1.6
Physical and Chemical Properties

4-chloro-N'-hydroxybenzenecarboximidamide - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
Hazard Class	IRRITANT

4-chloro-N'-hydroxybenzenecarboximidamide - Introduction

4-chloro-N '-hydroxybenzenecarboximidamide is an organic compound with the chemical formula C7H6ClN3O. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 4-chloro-N '-hydroxybenzenecarboximidamide is a white crystalline solid.
-Solubility: It is not easy to dissolve in water, but it can be dissolved in organic solvents, such as methanol, ethanol and dichloromethane.
-Melting point: Its melting point range is 182-186 degrees Celsius.

Use:
- 4-chloro-N '-hydroxybenzenecarboximidamide is used as an effective antibacterial agent in the field of medicine and is commonly used in the manufacture of various pharmaceutical preparations and disinfectants.
-It can also be used as an experimental reagent in the research field to synthesize and characterize other organic compounds.

Preparation Method:
4-chloro-N '-hydroxybenzenecarboximidamide can be prepared by the following steps:
-The first step is to generate 4-chloro-o-nitrobenzoic acid by reacting 4-chlorobenzoic acid with sodium nitrite.
-In the second step, 4-chloro-o-nitrobenzoic acid and ammonium sulfite are reacted to obtain 4-chloro-anthranilic acid.
-In the third step, 4-chloro-anthranilic acid is fluorinated using a fluorination reaction initiated by 2,2, 2-trifluoroacetic anhydride and bromine in the presence of a base to form 4-chloro-anthranilic acid.
-In the fourth step, 4-chloro-o-fluorobenzoic acid is reacted with ammonia to obtain 4-chloro-N '-hydroxybenzenecarboximidamide.

Safety Information:
- 4-chloro-N '-hydroxybenzenecarboximidamide is a chemical that requires proper management and handling to avoid inhalation, contact with skin or ingestion.
-Wear appropriate protective equipment such as gloves, goggles and lab coats when using it.
-In storage, should keep dry, cool, well-ventilated environment.
-When handling waste, follow the appropriate environmental regulations and safety regulations, and properly handle and dispose of chemical waste.

Last Update：2024-04-09 02:00:46