4-tert-Butoxy-3-oxobutyric acid ethyl ester

4-tert-Butoxy-3-oxobutyric acid ethyl ester - Names and Identifiers

Name	ethyl 4-tert-butoxy-3-oxobutanoate
Synonyms	ETHYL 4-TERT-BUTOXYACETOACETATE Ethyl 4-tert-butoxyacetoacetate ethyl4-tert-butoxy-3-oxobutanoate ethyl 4-tert-butoxy-3-oxobutanoate 4-tert-Butoxy-3-oxobutyric acid ethyl ester Butanoic acid, 4-(1,1-dimethylethoxy)-3-oxo-, ethyl ester
CAS	67354-35-2
InChI	InChI=1/C10H18O4/c1-5-13-9(12)6-8(11)7-14-10(2,3)4/h5-7H2,1-4H3

4-tert-Butoxy-3-oxobutyric acid ethyl ester - Physico-chemical Properties

Molecular Formula	C10H18O4
Molar Mass	202.25
Density	1.008
Boling Point	267 °C
Flash Point	111 °C
Vapor Presure	0.008mmHg at 25°C
pKa	9.90±0.46(Predicted)
Refractive Index	1.431

4-tert-Butoxy-3-oxobutyric acid ethyl ester - Introduction

Ethyl 4-tert-butoxy-3-oxobutanoate is an organic compound with the chemical formula C10H18O4. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: colorless liquid
-Molecular weight: 202.25g/mol
-Boiling Point: 167-168°C
-Melting point:-15°C
-Density: 0.99g/cm³
-Solubility: Soluble in ethanol, alcohols and ether solvents, insoluble in water

Use:
ethyl 4-tert-butoxy-3-oxobutanoate is often used as an intermediate and reagent in chemical synthesis. It can be used to synthesize biologically active molecules or as a protecting group for organic synthesis reactions.

Preparation Method:
Ethyl 4-tert-butoxy-3-oxobutanoate can be synthesized by the following steps:
1. Under suitable conditions, tetra-tert-butoxyboronic acid reacts with ethyl acetate to generate tetra-tert-butoxyethylboronic acid ethyl ester.
2. react tetra-tert-butoxyethyl borate with acetic anhydride to generate ethyl 4-tert-butoxy-3-oxobutanoate.

Safety Information:
Use and handle ethyl 4-tert-butoxy-3-oxobutanoate to follow general chemical laboratory safety practices. It is a flammable liquid and should avoid contact with open flames, high temperatures and oxidants. Contact with skin and eyes may cause irritation, so wear appropriate protective gloves and glasses. If ingested or inhaled, seek medical attention immediately.

Last Update：2024-04-10 22:29:15