4-tert-butyl-2-hydroxybenzoic acid

4-tert-butyl-2-hydroxybenzoic acid - Names and Identifiers

Name	2-Hydroxy-4-(2-methyl-2-propanyl)benzoic acid
Synonyms	4-tert-butyl-2-hydroxybenzoic acid 4-(tert-Butyl)-2-hydroxybenzoic acid 4-(1,1-Dimethylethyl)-2-hydroxybenzoic acid 2-Hydroxy-4-(2-methyl-2-propanyl)benzoic acid Benzoic acid, 4-(1,1-diMethylethyl)-2-hydroxy-
CAS	4578-63-6
InChI	InChI=1S/C11H14O3/c1-11(2,3)7-4-5-8(10(13)14)9(12)6-7/h4-6,12H,1-3H3,(H,13,14)

4-tert-butyl-2-hydroxybenzoic acid - Physico-chemical Properties

Molecular Formula	C11H14O3
Molar Mass	194.23
Density	1.162±0.06 g/cm3(Predicted)
Melting Point	154-155 °C
Boling Point	319.3±35.0 °C(Predicted)
pKa	3.19±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
MDL	MFCD16999904

4-tert-butyl-2-hydroxybenzoic acid - Introduction

2-Hydroxy-4-(2-methyl-2-propanyl)benzoic acid is an organic compound with the chemical formula C10H14O3. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Colorless crystalline solid.
-Melting point: about 153-156°C.
-Solubility: Soluble in alcohol, ether and benzene and other organic solvents.

Use:
2-Hydroxy-4-(2-methyl-2-propanyl)benzoic acid is often used as an important raw material and intermediate in organic synthesis. It can be used as one of the raw materials for drug synthesis in the field of medicine, such as the synthesis of anti-rheumatic drugs. In addition, it can be used as an intermediate in the synthesis of cosmetics, fragrances and dyes.

Preparation Method:
2-Hydroxy-4-(2-methyl-2-propanyl)benzoic acid can be obtained by reacting benzoyl chloride with tert-butyl lithium. The specific steps are as follows: firstly, benzoyl chloride is reacted with tert-butyl lithium at a low temperature to obtain a tert-butyl compound of the product benzoic acid; and then the compound is hydrolyzed with water or acid to generate 2-Hydroxy-4-(2-methyl-2-propanyl)benzoic acid.

Safety Information:
The safety information of 2-Hydroxy-4-(2-methyll-2-propanyl) benzoic acid needs to be evaluated and understood according to the safety regulations of the country or region where it is located. In general, chemicals should be stored in a dry, cool, well-ventilated place, away from fire and combustibles. Wear appropriate personal protective equipment to avoid contact with skin and eyes during operation. At the same time, it is necessary to strictly abide by the relevant operating procedures and safety operation guidelines. If necessary, professional waste disposal should be carried out.

Last Update：2024-04-09 21:11:58