5'-CHLORO-5'-DEOXYADENOSINE
9-(5-chloro-5-deoxypentofuranosyl)-9H-purin-6-amine
CAS: 892-48-8
Molecular Formula: C10H12ClN5O3
5'-CHLORO-5'-DEOXYADENOSINE - Names and Identifiers
| Name | 9-(5-chloro-5-deoxypentofuranosyl)-9H-purin-6-amine |
| Synonyms | 5'-CL-5'-DA 5'-Cl-5'-deoxyadenosine 5'-Deoxy-5'-chloroadenosine 5'-CHLORO-5'-DEOXYADENOSINE 5'-chloro-5'-deoxy-adenosin 5'-chloro-5'-deoxyadenosine Adenosine,5'-chloro-5'-deoxy- adenosine, 5'-chloro-5'-deoxy- 5'-CHLORO-5'-DEOXY-D-ADENOSINE 5-CHLORO-5-DEOXYADENOSINE HYDRATE 5'-CHLORO-5'-DEOXYADENOSINE MONOHYDRATE 9-(5-chloro-5-deoxypentofuranosyl)-9H-purin-6-amine 9H-purin-6-amine, 9-(5-chloro-5-deoxypentofuranosyl)- |
| CAS | 892-48-8 |
| InChI | InChI=1/C10H12ClN5O3/c11-1-4-6(17)7(18)10(19-4)16-3-15-5-8(12)13-2-14-9(5)16/h2-4,6-7,10,17-18H,1H2,(H2,12,13,14) |
5'-CHLORO-5'-DEOXYADENOSINE - Physico-chemical Properties
| Molecular Formula | C10H12ClN5O3 |
| Molar Mass | 285.69 |
| Density | 2.03±0.1 g/cm3(Predicted) |
| Melting Point | 187°C (exothermic decomp onset @144.5 C)(lit.) |
| Boling Point | 645.6±65.0 °C(Predicted) |
| Flash Point | 344.2°C |
| Solubility | DMSO (Slightly), Water (Slightly, Heated) |
| Vapor Presure | 1.5E-17mmHg at 25°C |
| Appearance | Solid |
| Color | Off-White to Light Beige |
| pKa | 13.03±0.70(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.87 |
5'-CHLORO-5'-DEOXYADENOSINE - Risk and Safety
| WGK Germany | 3 |
| RTECS | AU7357200 |
5'-CHLORO-5'-DEOXYADENOSINE - Reference Information
| Use | 5 '-chloro -5'-deoxyadenosine is the synthesis of 5 '-deoxy -5'-(methylthio) an intermediate of adenosine, a substrate for the Study of the specificity and kinetics of 5 '-methylthioadenosine phosphorylase (MTAP) (EC2). 4.2.28), an enzyme that inhibits the expression of a tumor suppressor gene, supporting the S-adenosylmethionine (AdoMet) and methionine salvage pathways. |
| preparation | 5 '-chloro-5'-deoxyadenosine is prepared from adenosine by selective chlorination. The synthesis reaction formula of 5 '-chloro-5'-deoxyadenosine is shown below: |
Last Update：2024-04-09 02:00:12
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