5'-O-(4,4'-Dimethoxytrityl)uridine

5'-O-(4,4'-Dimethoxytrityl)uridine - Names and Identifiers

Name	5'-O-(4,4'-Dimethoxytrityl)uridine
Synonyms	5'-DMT -rU DMT-RIBOURIDINE 5'-O-DMT-uridine 5'-O-DMTr-uridine 5'-O-(DIMETHOXYTRITYL)-URIDINE 5'-O-(4,4'-DiMethyltrityl) uridine 5'-O-(4,4'-Dimethoxytrityl)uridine 5'-O-(4,4'-DIMETHOXYTRITYL) URIDINE DTN-004 5'-O-(DiMethoxytrityl)-uridine
CAS	81246-79-9

5'-O-(4,4'-Dimethoxytrityl)uridine - Physico-chemical Properties

Molecular Formula	C30H30N2O8
Molar Mass	546.57
Density	1.343±0.06 g/cm3(Predicted)
Melting Point	111-112 °C(Solv: ethyl acetate (141-78-6))
pKa	9.39±0.10(Predicted)
Storage Condition	Store at 2-8°C

5'-O-(4,4'-Dimethoxytrityl)uridine - Introduction

5 '-O-(4,4'-Dimethoxytrityl)uridine is an organic compound with a chemical formula of C40H37N2O6 and a molecular weight of 631.74g/mol. It is a derivative of uridine in which the oxygen atom of urea is esterified with the hydroxyl group at the 5 '-position to form an ester bond.

This compound is mainly used as a protecting group in the chemical synthesis of nucleic acids. 4,4 '-Dimethoxytrityl (DMTr) is one of the commonly used nucleoside protecting groups, which can protect the active hydroxyl group of uridine to prevent its accidental reaction in the synthesis reaction. Using 5 '-O-(4,4'-Dimethoxytrityl)uridine as an intermediate, various nucleoside or nucleotide derivatives can be synthesized, which are used in the fields of drug discovery, DNA synthesis and biomedical research.

The preparation of 5 '-O-(4,4'-Dimethoxytrityl)uridine is generally accomplished by esterification of uridine with 4,4 '-dimethoxytrityl chloride under alkaline conditions. This reaction is usually carried out in the absence of a solvent or in an organic solvent, and the target product is obtained by isolation and purification.

Regarding safety information, since 5 '-O-(4,4'-Dimethoxytrityl)uridine is an organic compound, attention should be paid to safety when handling and using. It may cause some irritation to the human body, so necessary safety measures should be taken in the laboratory, such as wearing appropriate protective equipment (such as gloves, goggles and laboratory coats). In addition, the compound should be stored in a dry, dark and low temperature environment, away from fire and oxidizing agents.

Last Update：2024-04-09 21:04:16