5'-S-Methyl-5'-Thioadenosine

5'-S-Methyl-5'-Thioadenosine - Names and Identifiers

Name	5'-DEOXY-5'-METHYLTHIOADENOSINE
Synonyms	NSC 335422 5'-S-Methyl-5'-thioadenosine 5'-Deoxy(Methylthio)adenosine 5'-DEOXY-5'-METHYLTHIOADENOSINE 7-(5-Methylthio-5-deoxy-D-ribofuranosyl)-7H-purine-6-amine 2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol 7-[Tetrahydro-3α,4α-dihydroxy-5β-(methylthiomethyl)furan-2-yl]-7H-purin-6-amine
CAS	2457-80-9

5'-S-Methyl-5'-Thioadenosine - Physico-chemical Properties

Molecular Formula	C11H15N5O3S
Molar Mass	297.33
Density	1.85±0.1 g/cm3(Predicted)
Melting Point	210-213 °C (dec.)
Boling Point	642.7±65.0 °C(Predicted)
Solubility	DMF (Sparingly), DMSO (Slightly), Methanol (Slightly)
Appearance	White solid
Color	White to Off-White
BRN	42420
pKa	13.10±0.70(Predicted)
Storage Condition	-20°C
Physical and Chemical Properties	Biologically active 5 '-Methylthioadenosine is produced by S-adenylic acid and has a potent inhibitory effect.
Use	Introduction 5-deoxy-5-methylthioadenosine is an adenosine in which the C- 5 'hydroxyl group is substituted with methylthio (methylthio) and is useful as an inhibitor.
Target	Human Endogenous Metabolite
In vitro study	5'-Methylthioadenosine (MTA) can affect cellular processes in many ways. 5'-Methylthioadenosine has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous 5'-Methylthioadenosine could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for 5'-Methylthioadenosine that deserves further consideration [1] .

5'-S-Methyl-5'-Thioadenosine - Risk and Safety

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
RTECS	AU7410000
FLUKA BRAND F CODES	10-21

5'-S-Methyl-5'-Thioadenosine - Upstream Downstream Industry

Raw Materials

Adenosine, 5'-S-methyl-2',3'-O-(1-methylethylidene)-5'-thio- (9CI)
methylthioadenosine sulfoxide
5'-CHLORO-5'-DEOXYADENOSINE
Sodium thiomethoxide
Adenosine triphosphate

5'-S-Methyl-5'-Thioadenosine - Introduction

5 '-deoxy-5'-methylthioadenosine (5 '-deoxy-5'-methylthioadenosine) is a chemical substance that has the following properties:

-Appearance: 5 '-deoxy-5'-methylthioadenosine is a colorless to slightly yellow crystalline solid.
-Solubility: It can be dissolved in water, can also be dissolved in alcohol and dimethyl sulfoxide and other organic solvents.
-Chemical properties: It is a nucleoside, a nucleotide composed of adenine base and deoxyribose. It is a key metabolite in organisms and participates in many biochemical reactions.

5 '-Deoxy-5'-Methylthioadenosine has many uses in biological research:

-As an antibiotic: 5 '-deoxy-5'-methylthioadenosine can be used as an antibiotic and has a bactericidal effect on bacteria.
-As a Biochemical reagent: It is often used as a Biochemical reagent in the laboratory for the synthesis of DNA and RNA, as well as for enzyme kinetics and metabolism research.
-As a drug: Some studies have shown that 5 '-deoxy-5'-methylthioadenosine has an inhibitory effect on certain tumor cells and can be used as a potential anti-cancer drug.

The preparation of 5 '-deoxy-5'-methylthioadenosine is usually carried out by chemical synthesis. The most common method is by reacting the appropriate 5 '-chloroadenosine with a thiol.

Regarding safety information, 5 '-deoxy-5'-methylthioadenosine is relatively safe in general, but it is still necessary to follow safety procedures. It may cause irritation to the skin, eyes and respiratory system, so be careful to avoid contact during operation. In addition, the dosage and concentration need to be strictly controlled when used to avoid potential toxic effects. If necessary, it is recommended to use under the guidance of professionals.

Last Update：2024-04-09 20:52:54