5,5-Difluoro-1,3-piperidinedicarboxylic acid tert-butyl ester
5,5-Difluoro-1,3-piperidinedicarboxylicacid tert-butyl ester
CAS: 1255666-86-4
Molecular Formula: C11H17F2NO4
5,5-Difluoro-1,3-piperidinedicarboxylic acid tert-butyl ester - Names and Identifiers
5,5-Difluoro-1,3-piperidinedicarboxylic acid tert-butyl ester - Physico-chemical Properties
| Molecular Formula | C11H17F2NO4 |
| Molar Mass | 265.25 |
| Density | 1.27±0.1 g/cm3(Predicted) |
| Boling Point | 356.4±42.0 °C(Predicted) |
| pKa | 3.66±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | Irritant |
| MDL | MFCD18433630 |
5,5-Difluoro-1,3-piperidinedicarboxylic acid tert-butyl ester - Introduction
5,5-Difluoro-1, tert-butyl ester(5,5-Difluoro-1, tert-butyl ester) is a compound with the following properties:
Appearance: colorless liquid
Molecular formula: C11H16F2N2O4
Molecular weight: 284.25g/mol
Melting point: 54-55°C
Boiling point: 296-297°C
Solubility: Soluble in alcohol and ether solvents, slightly soluble in water.
5,5-Difluoro-1, tert-butyl is commonly used in organic synthesis as an intermediate in the synthesis of drugs, pesticides, and other organic compounds. It is also used in the preparation of piperidines in drug development.
The preparation method can be synthesized by the following steps:
1. First, 2,2-difluoro -1,3-diphenylpent-1-ene (2,2-Difluoro-1,3-dibenzylpent-4-ene) and methylpropiolic acid (methyl propargylacetate) were subjected to catalytic addition reaction in dimethyl sulfoxide to obtain 2,2-difluoro -1,3-diphenylpentylpropiolic acid.
2. The above product is reacted with tert-butyl alcohol acid (tert-butanic acid) in an anhydrous environment to generate 5,5-Difluoro-1, tert-butyl ester.
Safety information, 5,5-Difluoro-1, the tert-butyl ester should be handled properly, avoid contact with skin and eyes. Wear appropriate protective gloves and eye protection during operation. At the same time, it should be operated in a well-ventilated place to avoid inhaling its vapor. If exposed or inhaled, seek medical attention as soon as possible.
Appearance: colorless liquid
Molecular formula: C11H16F2N2O4
Molecular weight: 284.25g/mol
Melting point: 54-55°C
Boiling point: 296-297°C
Solubility: Soluble in alcohol and ether solvents, slightly soluble in water.
5,5-Difluoro-1, tert-butyl is commonly used in organic synthesis as an intermediate in the synthesis of drugs, pesticides, and other organic compounds. It is also used in the preparation of piperidines in drug development.
The preparation method can be synthesized by the following steps:
1. First, 2,2-difluoro -1,3-diphenylpent-1-ene (2,2-Difluoro-1,3-dibenzylpent-4-ene) and methylpropiolic acid (methyl propargylacetate) were subjected to catalytic addition reaction in dimethyl sulfoxide to obtain 2,2-difluoro -1,3-diphenylpentylpropiolic acid.
2. The above product is reacted with tert-butyl alcohol acid (tert-butanic acid) in an anhydrous environment to generate 5,5-Difluoro-1, tert-butyl ester.
Safety information, 5,5-Difluoro-1, the tert-butyl ester should be handled properly, avoid contact with skin and eyes. Wear appropriate protective gloves and eye protection during operation. At the same time, it should be operated in a well-ventilated place to avoid inhaling its vapor. If exposed or inhaled, seek medical attention as soon as possible.
Last Update：2024-04-09 21:48:26
