5-甲基吡啶-2-硼酸
5-Methyl-2-pyridineboronic acid
CAS: 372963-49-0
Molecular Formula: C6H8BNO2
5-甲基吡啶-2-硼酸 - Names and Identifiers
5-甲基吡啶-2-硼酸 - Physico-chemical Properties
| Molecular Formula | C6H8BNO2 |
| Molar Mass | 136.94 |
| Density | 1.18±0.1 g/cm3(Predicted) |
| Melting Point | 86-90 |
| Boling Point | 314.6±44.0 °C(Predicted) |
| Flash Point | 144.1°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0.000196mmHg at 25°C |
| pKa | 8.11±0.53(Predicted) |
| Storage Condition | Store below -20℃ |
| Refractive Index | 1.527 |
5-甲基吡啶-2-硼酸 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S39 - Wear eye / face protection. |
| Hazard Note | Irritant/Store below -20°C |
5-甲基吡啶-2-硼酸 - Introduction
5-Methyl-2-pyridineboronic acid is an organoboron compound with the chemical formula C6H8BNO2 and molecular weight of 141.95g/mol. It is a white solid, soluble in polar solvents such as water, ethanol and methylene chloride.
5-Methyl-2-pyridineboronic acid can be used as an important reagent in organic synthesis. It is often used as a source of boronic acid groups in aromatic compounds. The boronic acid group has special reactivity in organic synthesis, and can participate in various reactions such as benzene ring activation, nitrogen heterocyclic ring activation, alcohol hydroxyl protection, ketone carbonyl protection and so on. Therefore, 5-Methyl-2-pyridineboronic acid is widely used in the synthesis of drugs, pesticides and other important compounds.
the preparation method of 5-Methyl-2-pyridineboronic acid is generally obtained by reacting boric acid with the corresponding aromatic substituted pyridine under alkaline conditions. The specific step is to first react aryl-substituted pyridine and boric acid under alkaline conditions to form a borate intermediate, and then hydrolyze under acidic conditions to generate 5-Methyl-2-pyridineboronic acid.
Regarding safety information, 5-Methyl-2-pyridineboronic acid may cause irritation to the eyes, skin, and respiratory tract, and contact should be avoided. Good laboratory practices should be followed during use, including the wearing of appropriate personal protective equipment. When handling this compound, the production of dust and aerosols should be avoided as much as possible.
5-Methyl-2-pyridineboronic acid can be used as an important reagent in organic synthesis. It is often used as a source of boronic acid groups in aromatic compounds. The boronic acid group has special reactivity in organic synthesis, and can participate in various reactions such as benzene ring activation, nitrogen heterocyclic ring activation, alcohol hydroxyl protection, ketone carbonyl protection and so on. Therefore, 5-Methyl-2-pyridineboronic acid is widely used in the synthesis of drugs, pesticides and other important compounds.
the preparation method of 5-Methyl-2-pyridineboronic acid is generally obtained by reacting boric acid with the corresponding aromatic substituted pyridine under alkaline conditions. The specific step is to first react aryl-substituted pyridine and boric acid under alkaline conditions to form a borate intermediate, and then hydrolyze under acidic conditions to generate 5-Methyl-2-pyridineboronic acid.
Regarding safety information, 5-Methyl-2-pyridineboronic acid may cause irritation to the eyes, skin, and respiratory tract, and contact should be avoided. Good laboratory practices should be followed during use, including the wearing of appropriate personal protective equipment. When handling this compound, the production of dust and aerosols should be avoided as much as possible.
Last Update：2024-04-09 20:02:46
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View History
5-甲基吡啶-2-硼酸
BIS(3,5-DIMETHYLPHENYL)PHOSPHINE
2-[(4-乙氧苯基)氨基]-4-硝基-苯甲酸
ETHYL (TRIPHENYLPHOSPHORANYLIDEN)ACETATE
顺-D-羟脯氨酸
2-氨基-4-叔丁基苯酚,2-氨基-4-叔丁基酚,邻氨基对叔丁基苯酚
(2S,3R)-3-氨基-2-羟基-4-苯丁酸 乌苯美司中间体
3-氟-4-硝基碘苯
(SP-4-1)-[1,3-双[2,6-双(1-丙基丁基)苯基]-4,5-二氯-1,3-二氢-2H-咪唑-2-基亚基]二氯(3-氯吡啶-ΚN)钯
cannot calculate
BIS(3,5-DIMETHYLPHENYL)PHOSPHINE
2-[(4-乙氧苯基)氨基]-4-硝基-苯甲酸
ETHYL (TRIPHENYLPHOSPHORANYLIDEN)ACETATE
顺-D-羟脯氨酸
2-氨基-4-叔丁基苯酚,2-氨基-4-叔丁基酚,邻氨基对叔丁基苯酚
(2S,3R)-3-氨基-2-羟基-4-苯丁酸 乌苯美司中间体
3-氟-4-硝基碘苯
(SP-4-1)-[1,3-双[2,6-双(1-丙基丁基)苯基]-4,5-二氯-1,3-二氢-2H-咪唑-2-基亚基]二氯(3-氯吡啶-ΚN)钯
cannot calculate