5-(2-Chloroethyl)indoline, N-BOC protected

5-(2-Chloroethyl)indoline, N-BOC protected - Names and Identifiers

Name	1H-Indole-1-carboxylic acid, 5-(2-chloroethyl)-2,3-dihydro-, 1,1-diMethylethyl ester
Synonyms	5-(2-Chloroethyl)indoline, N-BOC protected tert-Butyl 5-(2-chloroethyl)indoline-1-carboxylate tert-Butyl 5-(2-chloroethyl)-2,3-dihydro-1H-indole-1-carboxylate 1H-Indole-1-carboxylic acid, 5-(2-chloroethyl)-2,3-dihydro-, 1,1-diMethylethyl ester 5-(2-Chloroethyl)-2,3-dihydro-1H-indole, N-BOC protected, tert-Butyl 5-(2-chloroethyl)-2,3-dihydro-1H-indole-1-carboxylate, 1-(tert-Butoxycarbonyl)-5-(2-chloroethyl)-2,3-dihydro-1H-indole
CAS	860024-94-8

5-(2-Chloroethyl)indoline, N-BOC protected - Physico-chemical Properties

Molecular Formula	C15H20ClNO2
Molar Mass	281.78
Boling Point	410.2±30.0 °C
Storage Condition	2-8°C

5-(2-Chloroethyl)indoline, N-BOC protected - Introduction

1H-Indole-1-carboxylic acid, 5-(2-chloroethyl)-2,3-dihydro-, 1,1-dimethyleyl ester is an organic compound whose structural formula is:

It is an indoline derivative containing chloroethyl and N-Boc protecting groups. The following is a detailed description of its nature, use, preparation and safety information:

Nature:
-Appearance: 1H-Indole-1-carboxylic acid, 5-(2-chloroethyl)-2,3-dihydro-, 1,1-dimethanol ester is a solid, usually white to light yellow crystals.
-Melting point: According to literature reports, its melting point range is 85-88 degrees Celsius.
-Solubility: It is soluble in some organic solvents, such as ethanol, dimethylformamide (DMF) and dichloromethane.

Use:
1H-indole-1-carboxylic acid, 5-(2-chloroethyl)-2,3-dihydro-, 1,1-dimethylethyl ester has certain application value in organic synthesis and can be used to construct the structure of indoline compounds. It acts as an intermediate compound that can be further converted into other organic compounds by reaction.

Preparation Method:
The specific details of the preparation method may be different. The following is a reference preparation method:
1H-Indole-1-carboxylic acid, 5-(2-chloroethyl)-2,3-dihydro-, 1,1-dimethylethyl ester can be obtained by reacting 5-chloroacetyl chloride with N-Boc-indoline under alkaline conditions. The reaction is generally carried out in a suitable solvent and at low temperature. After the reaction, steps such as purification and crystallization are required.

Safety Information:
Because the safety of a chemical depends on factors such as its specific quality, purity, and conditions of use, consult a reliable chemical database or relevant literature for detailed safety information and operational measures before using or operating the chemical. At the same time, it is recommended to follow correct laboratory safety procedures and use personal protective equipment when conducting chemical experiments or operations.

Last Update：2024-04-09 21:04:16