5-Aminolevulinic acid hydrochloride

5-Aminolevulinic acid hydrochloride - Names and Identifiers

Name	5-Aminolevulinic acid hydrochloride
Synonyms	evuL 5-Ala 5-AminoL inic acid hydrochL TIMTEC-BB SBB003880 d-Aminolevulinic Acid, HCl 5-Amino-15N-levulinic Acid HCl 5-Aminolevulinic-3-13C Acid HCl 5-amino-3-oxopentanoic acid, HCl Aminolevulinic Acid Hydrochloride 5-Aminolevulinicacid hydrochloride 5-Aminolevulinic acid hydrochloride 5-Amino-4-ketovaleric acid hydrochloride 5-AminolevulinicAcidHydrochloride(5-Ala) DELTA-AMINOLEVULINIC ACID HYDROCHLORIDE CELL CULTUR
CAS	5451-09-2
EINECS	226-679-5
InChI	InChI=1/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H
InChIKey	ZLHFONARZHCSET-UHFFFAOYSA-N

5-Aminolevulinic acid hydrochloride - Physico-chemical Properties

Molecular Formula	C5H10ClNO3
Molar Mass	167.59
Melting Point	~150°C (dec.)
Boling Point	298.4°C at 760 mmHg
Flash Point	155-157°C
Water Solubility	Soluble in dimethyl sulfoxide, methanol and water.
Solubility	H2O: 50mg/mL
Vapor Presure	0.000303mmHg at 25°C
Appearance	Solid
Color	White to pale yellow
Merck	14,446
BRN	3690651
PH	pH (10g/l, 25℃) : 2.5～3.0
Storage Condition	-20°C
Sensitive	Hygroscopic
MDL	MFCD00012869
Physical and Chemical Properties	Melting point 156-158°C DECOMPOSITION 155-157°C
In vitro study	5-Aminolevulinic acid(5-ALA)-Photodynamic therapy (PDT) results in downregulation of nuclear factor kappb (NFkappaB) and baculovirus containing an inhibitor of apoptosis of the -3(BIRC-3) protein repeat. 5-Aminolevulinic acid(5-ALA)-Photodynamic therapy (PDT) resulted in an increase in Bax expression: the ratio of Bcl-2 and mitochondrial release of cytochrome c and apoptosis-inducing factor (AIF). 5-Aminolevulinic acid causes metal-catalyzed oxidation of reactive oxygen species, resulting in damage to rat liver mitochondria and DNA damage in vitro and in vivo. 5-Aminolevulinic acid dose-dependently induced nuclear and mitochondrial DNA damage in human SVNF fibroblasts and rat PC12 cells. 5-Aminolevulinic acid dose-dependently reduced cAMP levels (maximum inhibition of 38% at 1mm) due to inhibition of basaladenylate cyclase activity. 5-Aminolevulinic acid also inhibited fluoride-and Gpp(NH)p-stimulated, but not forskolin-stimulated, adenylate cyclase activity. In isolated membranes from rat cortex and striatum and human cerebral cortex, 5-Aminolevulinic acid also inhibited adenylate cyclase activity. 5-Aminolevulinic acid(0-3 mM) inhibited glutamate uptake by astrocytes in a dose-dependent manner. 5-Aminolevulinic acid significantly reduced the K(m) and V(max) of glutamate uptake, indicating non-competitive inhibition. In cultured astrocytes under these conditions, 5-Aminolevulinic acid significantly increased lipid peroxidation in astrocytes. 5-Aminolevulinic acid-mediated sonodynamic therapy exhibited synergistic apoptotic effects THP-1 macrophages, involving excessive intracellular reactive oxygen species production and MMP loss.

5-Aminolevulinic acid hydrochloride - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R66 - Repeated exposure may cause skin dryness or cracking R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/38 - Irritating to eyes and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing.
WGK Germany	3
RTECS	OI1640000
FLUKA BRAND F CODES	3-8-10
HS Code	29224999
Hazard Note	Irritant

5-Aminolevulinic acid hydrochloride - Reference

Reference

1. [IF=3.31] Ali Maruf et al."Nanoerythrocyte Membrane–Enveloped ROS-Responsive 5-Aminolevulinic Acid Prodrug Nanostructures with Robust Atheroprotection."Part Part Syst Char. 2020 May;37(5):2000021

5-Aminolevulinic acid hydrochloride - Security information

dangerous goods mark	Xi,Xn
hazard category code	36/37/38-66-20/21/22-36/38
safety instructions	26-36/37-37/39-36
WGK Germany	3
RTECS number	OI1640000
F	3-8-10
Hazard Note	Irritant
customs code	29224999

Last Update：2024-04-10 22:29:15

5-Aminolevulinic acid hydrochloride - Uses and synthesis methods

main function

5-aminolevulinic acid hydrochloride is mainly used as a substrate for 5-aminolevulinic acid dehydrogenase, biochemical research.

use

5-aminolevulinic acid hydrochloride is a natural amino acid; it is used as a precursor of tetrapyrrole for the biosynthesis of chlorophyll and heme; an anti-tumor drug (photosensitizer).

biological activity

5-Aminolevulinic acid HCl is an intermediate of heme biosynthesis in the body and a prodrug of tetrapyrrole.

Target

Human Endogenous Metabolite

Last Update：2024-04-10 22:41:56

5-Aminolevulinic acid hydrochloride - Nature

melting point	~150°C (dec.)
flash point	155-157°C
storage conditions	-20°C
solubility	H2O: 50 mg/mL
morphology	powder
color	White to pale yellow
PH value	pH (10g/l, 25℃) : 2.5~3.0
water solubility	Soluble in dimethyl sulfoxide, methanol and water.
sensitivity	Hygroscopic
Decomposition	155-157 °C
Merck	14,446
BRN	3690651
InChIKey	ZLHFONARZHCSET-UHFFFAOYSA-N

Last Update：2024-04-09 19:04:54

5-Aminolevulinic acid hydrochloride - Reference Information

Decomposition	155-157 ºC
Main effects	5-aminolevulinic acid hydrochloride is mainly used as a substrate for 5-aminolevulinic acid dehydrogenase, biochemical research.
Uses	5-aminolevulinic acid hydrochloride is a natural amino acid; as a precursor of tetrapyrrole for the biosynthesis of chlorophyll and heme; anti-tumor drugs (photosensitizers).
Biological activity	5-Aminolevulinic acid HCl is an intermediate in the biosynthesis of heme in the body and a prodrug of tetrapyrrole.

Last Update：2024-04-09 21:01:54

Taixing Joxin Bio-tec Co.,Ltd.

Featured ProductsSpot supply

Product Name: 5-Aminolevulinic acid hydrochloride Request for quotation
CAS: 5451-09-2
Tel: 86-523-87558858,87612088
Email: 184089063@qq.com
　　　　 yhj@joxbio.com
Mobile: 86-13615177555,15371578585,15370719785
QQ: 184089063

Wechat: JOXBIO

SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.

Featured ProductsSpot supply

Product Name: 5-Aminolevulinic acid hydrochloride Visit Supplier Webpage Request for quotation
CAS: 5451-09-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922

Wechat: 18621343501
WhatsApp: +86-18621343501

Guangzhou Yuanda New Material Co.,Ltd

Multiple Specifications

Product Name: 5-Aminolevulinic acid hydrochloride Request for quotation
CAS: 5451-09-2
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589

Wuhan Boye Science And Technology Development Co., Ltd.

Product Name: 5-ALA Hcl IN-HOUSE Request for quotation
CAS: 5451-09-2
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380

BOC Sciences

Spot supply

Product Name: Aminolevulinic Acid hydrochloride Visit Supplier Webpage Request for quotation
CAS: 5451-09-2
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog

MedChemExpress (MCE)

Multiple SpecificationsSpot supply

Product Name: 5-Aminolevulinic acid hydrochloride Visit Supplier Webpage Request for quotation
CAS: 5451-09-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: 5-Aminolevulinic acid hydrochloride Request for quotation
CAS: 5451-09-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Macklin Biochemical Co., Ltd

Spot supply

Product Name: 5-Aminolevulinic acid hydrochloride Visit Supplier Webpage Request for quotation
CAS: 5451-09-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

Shanghai Yuanye Bio-Technology Co., Ltd.

Spot supply

Product Name: 5-Aminolevulinic acid hydrochloride Visit Supplier Webpage Request for quotation
CAS: 5451-09-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Zouping Mingxing Chemical Co., Ltd.

Product Name: 5-Aminolevulinic acid hydrochloride Request for quotation
CAS: 5451-09-2
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987

WhatsApp: 13605431940

Taixing Joxin Bio-tec Co.,Ltd.

Featured ProductsSpot supply

Wechat: JOXBIO

SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.

Featured ProductsSpot supply

Product Name: 5-Aminolevulinic acid hydrochloride Visit Supplier Webpage Request for quotation
CAS: 5451-09-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922

Wechat: 18621343501
WhatsApp: +86-18621343501

Guangzhou Yuanda New Material Co.,Ltd

Multiple Specifications

Product Name: 5-Aminolevulinic acid hydrochloride Request for quotation
CAS: 5451-09-2
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589

Wuhan Boye Science And Technology Development Co., Ltd.

Product Name: 5-ALA Hcl IN-HOUSE Request for quotation
CAS: 5451-09-2
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380

BOC Sciences

Spot supply

MedChemExpress (MCE)

Multiple SpecificationsSpot supply

Hefei TNJ Chemical Industry Co.,Ltd.

Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Macklin Biochemical Co., Ltd

Spot supply

Product Name: 5-Aminolevulinic acid hydrochloride Visit Supplier Webpage Request for quotation
CAS: 5451-09-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

Shanghai Yuanye Bio-Technology Co., Ltd.

Spot supply

Product Name: 5-Aminolevulinic acid hydrochloride Visit Supplier Webpage Request for quotation
CAS: 5451-09-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Zouping Mingxing Chemical Co., Ltd.

Product Name: 5-Aminolevulinic acid hydrochloride Request for quotation
CAS: 5451-09-2
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987

WhatsApp: 13605431940

View History

5-Aminolevulinic acid hydrochloride
Ganciclovir impurities818
N-(4-BROMO-2-METHOXY-PHENYL)-ACETAMIDE
sodium (4Z)-4-[2-(1-hydroxynaphthalen-2-yl)hydrazinylidene]-3-oxo-3,4-dihydronaphthalene-1-sulfonate

5-Aminolevulinic acid hydrochloride

5-Aminolevulinic acid hydrochloride

CAS: 5451-09-2

Molecular Formula: C5H10ClNO3

5-Aminolevulinic acid hydrochloride - Names and Identifiers

5-Aminolevulinic acid hydrochloride - Physico-chemical Properties

5-Aminolevulinic acid hydrochloride - Risk and Safety

5-Aminolevulinic acid hydrochloride - Reference

5-Aminolevulinic acid hydrochloride - Security information

5-Aminolevulinic acid hydrochloride - Uses and synthesis methods

5-Aminolevulinic acid hydrochloride - Nature

5-Aminolevulinic acid hydrochloride - Reference Information

Supplier List

5-Aminolevulinic acid hydrochloride Request for Quotation

5-Aminolevulinic acid hydrochloride

CAS: 5451-09-2

Molecular Formula: C5H10ClNO3

5-Aminolevulinic acid hydrochloride - Names and Identifiers

5-Aminolevulinic acid hydrochloride - Physico-chemical Properties

5-Aminolevulinic acid hydrochloride - Risk and Safety

5-Aminolevulinic acid hydrochloride - Reference

5-Aminolevulinic acid hydrochloride - Security information

5-Aminolevulinic acid hydrochloride - Uses and synthesis methods

5-Aminolevulinic acid hydrochloride - Nature

5-Aminolevulinic acid hydrochloride - Reference Information

Supplier List

5-Aminolevulinic acid hydrochloride