5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-
WAY-200070
CAS: 440122-66-7
Molecular Formula: C13H8BrNO3
5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)- - Names and Identifiers
5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)- - Physico-chemical Properties
| Molecular Formula | C13H8BrNO3 |
| Molar Mass | 306.11 |
| Density | 1.720±0.06 g/cm3(Predicted) |
| Boling Point | 463.6±35.0 °C(Predicted) |
| Solubility | DMSO: ≥ 31 mg/mL |
| Appearance | solid |
| pKa | 7.26±0.40(Predicted) |
| Storage Condition | Store at RT |
| In vivo study | Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test. |
5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)- - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| Hazard Class | 6.1 |
5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.267 ml | 16.334 ml | 32.668 ml |
| 5 mM | 0.653 ml | 3.267 ml | 6.534 ml |
| 10 mM | 0.327 ml | 1.633 ml | 3.267 ml |
| 5 mM | 0.065 ml | 0.327 ml | 0.653 ml |
Last Update：2024-01-02 23:10:35
5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)- - Reference Information
| biological activity | WAY-200070 is a selective estrogen receptor agonist with an IC50 value of 2.3 nM. |
| Target | IC50: 2.3 nM (ERR β), 155 nM (ERR α) |
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: WAY-200070 Visit Supplier Webpage Request for quotationCAS: 440122-66-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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