5-BroMo-2-fluoro-3-pyridinecarboxylic acid

5-BroMo-2-fluoro-3-pyridinecarboxylic acid - Names and Identifiers

Name	5-Bromo-2-fluoronicotinic acid
Synonyms	LogP 5-BROMO-2-FLUORONICOTINIC ACID 5-Bromo-2-fluoronicotinic acid 2-Fluoro-5-bromonicotinic acid 5-bromo-2-fluoropyridine-3-carboxylicaci 5-Bromo-2-fluoropyridine-3-carboxylic acid 5-BroMo-2-fluoro-3-pyridinecarboxylic acid 3-Pyridinecarboxylic acid, 5-bromo-2-fluoro- 5-Bromo-2-fluoropyridine-3-carboxylic acid, 5-Bromo-3-carboxy-2-fluoropyridine
CAS	29241-66-5
InChI	InChI=1/C6H3BrFNO2/c7-3-1-4(6(10)11)5(8)9-2-3/h1-2H,(H,10,11)

5-BroMo-2-fluoro-3-pyridinecarboxylic acid - Physico-chemical Properties

Molecular Formula	C6H3BrFNO2
Molar Mass	220
Density	1.903±0.06 g/cm3(Predicted)
Boling Point	327.4±42.0 °C(Predicted)
Flash Point	151.8°C
Vapor Presure	8.22E-05mmHg at 25°C
pKa	2.15±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.589
MDL	MFCD06797939

5-BroMo-2-fluoro-3-pyridinecarboxylic acid - Risk and Safety

Hazard Class

IRRITANT

5-BroMo-2-fluoro-3-pyridinecarboxylic acid - Introduction

5-Bromo-2-fluoronicotinic acid, chemical formula C6H3BrFNO2, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Colorless or yellow solid
-Melting point: 166-170 ° C
-Boiling point: 324.7 ° C
-Solubility: Soluble in water and some organic solvents

Use:
5-Bromo-2-fluoronicotinic acid has certain application value in organic synthesis, and is mainly used to prepare other compounds, such as drugs, pesticides, dyes, etc.

Method:
The preparation of 5-Bromo-2-fluoronicotinic acid is generally carried out by the following steps:
1. First, ethyl bromophenylacetate and hydrogen fluoride hydrofluoric acid solution are reacted to produce ethyl 2-fluoro-5-bromophenylacetate.
2. Then, ethyl 2-fluoro-5-bromophenyl acetate was hydrolyzed under the catalysis of cuprous iodide to obtain 5-Bromo-2-fluoronicotinic acid.

Safety Information:
The toxicity and danger of 5-Bromo-2-fluoronicotinic acid is not fully understood, so necessary safety precautions should be taken when using it in the laboratory. If wearing protective goggles, protective gloves and laboratory coats, ensure that the operating environment is well ventilated. Avoid inhalation, chewing or skin contact when handling the compound, and store it properly to prevent contamination by external substances. If ingested or exposed, seek medical help immediately.

Last Update：2024-04-09 21:01:54