5-Bromo-2-chloro-3-nitropyridine
5-Bromo-2-chloro-3-nitropyridine
CAS: 67443-38-3
Molecular Formula: C5H2BrClN2O2
5-Bromo-2-chloro-3-nitropyridine - Names and Identifiers
| Name | 5-Bromo-2-chloro-3-nitropyridine |
| Synonyms | RARECHEM AL BO 2390 IFLAB-BB F1957-0001 5-BROMO-2-PICOLINIC ACID 5-BROMO-2-CARBOXYPYRIDINE 5-Bromo-2-chloro-3-nitrop... 5-Bromo-2-chloro-3-nitropyridine 2-Chloro-3-nitro-5-bromopyridine 2-CHLORO-5-BROMO-3-NITROPYRIDINE 2-PYRIDINECARBOXYLIC ACID, 5-BROMO- |
| CAS | 67443-38-3 |
| EINECS | 675-866-1 |
| InChI | InChI=1/C5H2BrClN2O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H |
5-Bromo-2-chloro-3-nitropyridine - Physico-chemical Properties
| Molecular Formula | C5H2BrClN2O2 |
| Molar Mass | 237.44 |
| Density | 1.936±0.06 g/cm3(Predicted) |
| Melting Point | 65-70 °C |
| Boling Point | 285.4±35.0 °C(Predicted) |
| Flash Point | 126.4°C |
| Solubility | DMSO, Methanol |
| Vapor Presure | 0.00483mmHg at 25°C |
| Appearance | Bright yellow powder |
| Color | Yellow |
| pKa | -4.99±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.627 |
| MDL | MFCD00222270 |
5-Bromo-2-chloro-3-nitropyridine - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R21/22 - Harmful in contact with skin and if swallowed. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R25 - Toxic if swallowed R22 - Harmful if swallowed |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Harmful |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
5-Bromo-2-chloro-3-nitropyridine - Reference Information
| Use | 5-bromo-2-chloro-3-nitropyridine (cas#67443-38-3) are compounds that can be used in organic synthesis. |
| Application | 5-bromo-2-chloro-3-nitropyridine can be mainly used as raw materials for organic synthesis and pharmaceutical intermediates, can be used in the laboratory of organic synthesis process and chemical medicine research and development process. |
| preparation | step A: 5-bromo-3-nitropyridine-2 (1H)-Ketone synthesis to a solution of 5-bromopyridin-2 (1H)-One (Aldrich,10g,57.5mmol) in sulfuric acid (60ml) was added nitric acid (60-61%, wako Pure Chemical Industries,Ltd.,20). mL) at 0 °c. The mixture was warmed to room temperature and stirred for 4.5 hours. The mixture was poured into ice-water and the precipitate was collected by filtration. The solid was washed with water and dried in vacuo to give the title compound (7.2g,57%) as a yellow solid. Step B: Synthesis of 5-bromo-3-nitropyridin-2 (1H) -one from 5-bromo-2-chloro-3-nitropyridine (Step A,7.2g,32.9mmol), a mixture of phosphorus oxychloride (72mL) and N,N-dimethylformamide (7.2mL) was stirred at reflux for 2 hours. After removal of the solvent, the residue was dissolved in water (100ml) and ethyl acetate (30ml) and the solution was separated. The organic layer was washed with saturated sodium bicarbonate, dried over sodium sulfate and concentrated to give the title compound 5-bromo-2-chloro-3-nitropyridine (6.97g,89%) as a light yellow solid. |
Last Update：2024-04-09 20:52:54
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