5-Bromo-2-methylnicotinic acid ethyl ester

5-Bromo-2-methylnicotinic acid ethyl ester - Names and Identifiers

Name	ethyl 5-bromo-2-methylpyridine-3-carboxylate
Synonyms	5-BroMo-2-Methylnicotini Ethyl 5-Bromo-2-Methylnicotinate Ethyl 5-broMo-2-Methylnicotinate 5-Bromo-2-methylnicotinic acid ethyl ester 5-BroMo-2-Methylnicotinic acid ethyl esther 5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER ethyl 5-bromo-2-methylpyridine-3-carboxylate ethyl 5-broMo-2-Methylpyridine-3-carboxylate 5-Bromo-2-methyl-3-pyridinecarboxylic acid ethyl ester 3-Pyridinecarboxylic acid, 5-broMo-2-Methyl-, ethyl ester 3-pyridinecarboxylic acid, 5-bromo-2-methyl-, ethyl ester
CAS	129477-21-0
InChI	InChI=1/C9H10BrNO2/c1-3-13-9(12)8-4-7(10)5-11-6(8)2/h4-5H,3H2,1-2H3

5-Bromo-2-methylnicotinic acid ethyl ester - Physico-chemical Properties

Molecular Formula	C9H10BrNO2
Molar Mass	244.09
Density	1.439
Melting Point	113℃
Boling Point	263℃
Flash Point	113℃
Water Solubility	Slightly soluble in water.
Vapor Presure	0.011mmHg at 25°C
Appearance	Solid
Color	Pale yellow
pKa	1.66±0.20(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.541
MDL	MFCD10698571

5-Bromo-2-methylnicotinic acid ethyl ester - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
HS Code	29333990

5-Bromo-2-methylnicotinic acid ethyl ester - Reference Information

use

ethyl 5-bromo-2-methylnicotinate is a carboxylate derivative and can be used as a pharmaceutical intermediate.

preparation

4. 9 g5-bromo -2-methyl nicotinate (0. 04 mol), absolute ethanol 40
mL, corresponding amount of concentrated sulfuric acid and phase transfer catalyst are sequentially added into 250 mL three-mouth bottle. The stirrer and distillation device are respectively installed. Heat under stirring, gradually heat up, evaporate the ethanol to the required liquid temperature, stop heating, naturally cool down, pour out at about
50°C, and the reactants are white solids at room temperature. Neutralize the product with saturated sodium carbonate aqueous solution to a pH of about 7 (if the volume is too large, some solid sodium carbonate can be added), extract it with 20
mL chloroform, merge the organic layers and transfer it to a vacuum distillation flask, first recover chloroform at normal pressure, then distill 5-bromo -2-methyl ethyl nicotinate under vacuum, collect 92 ~
95°C fraction at 1. 06 kPa, weigh it, and calculate the yield.

Last Update：2024-04-09 21:04:16