5-Bromo-3,4-dihydroquinolin-2(1H)-one is an organic compound with the chemical formula C9H8BrNO and a molecular weight of 227.07g/mol. It is a solid white crystal, soluble in organic solvents such as ether and chloroform.
The main use of this compound is as an intermediate in organic synthesis. It can be used to synthesize complex organic compounds such as drugs and pesticides. For example, it can be used as an important intermediate in the preparation of antibacterial drugs, antiviral drugs and antitumor drugs.
A common method for preparing 5-Bromo-3,4-dihydroquinolin-2(1H)-one is to acylate p-aminobenzoic acid to obtain p-aminobenzoyl chloride, and then react with ethyl acetate to form 3-ethoxyformanilide. Next, 3-ethoxyformanilide is converted to 5-Bromo-3,4-dihydroquinolin-2(1H)-one by a ring-closing reaction.
Regarding safety information, 5-Bromo-3,4-dihydroquinolin-2(1H)-one has less reported information on toxicity and harmfulness, but it is an irritant substance. During handling and handling, it is necessary to follow appropriate laboratory practices and take personal protective measures, such as wearing chemical protective gloves, goggles and protective clothing. Please read the relevant safety information carefully before use, and take corresponding measures to ensure safety according to the specific situation.