5-Bromo-3-pyridineboronic acid pinacol ester

5-Bromo-3-pyridineboronic acid pinacol ester - Names and Identifiers

Name	3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Synonyms	3-BROMOPYRIDINE-5-BORONIC ACID PINACOL ESTER 5-BROMOPYRIDINE-3-BORONIC ACID, PINACOL ESTER 5-Bromo-3-pyridineboronic acid pinacol ester 3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE Pyridine, 3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CAS	452972-13-3
EINECS	201-525-2
InChI	InChI=1/C11H15BBrNO2/c1-10(2)11(3,4)16-12(15-10)8-5-9(13)7-14-6-8/h5-7H,1-4H3

5-Bromo-3-pyridineboronic acid pinacol ester - Physico-chemical Properties

Molecular Formula	C11H15BBrNO2
Molar Mass	283.96
Density	1.34
Melting Point	63.4-63.8°C
Boling Point	341.4±27.0 °C(Predicted)
Flash Point	160.3°C
Vapor Presure	0.000159mmHg at 25°C
pKa	2.86±0.22(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.527

5-Bromo-3-pyridineboronic acid pinacol ester - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/38 - Irritating to eyes and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
Hazard Class	IRRITANT

5-Bromo-3-pyridineboronic acid pinacol ester - Introduction

3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is an organic compound whose chemical formula is C12H15BBrNO2.

Nature:
-Appearance: Colorless to light yellow crystal
-Melting point: 92-95°C
-Solubility: Soluble in organic solvents such as ether, dichloromethane and chloroform, insoluble in water.

Use:
3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine has important application value in organic synthesis, and can be used as ligand, catalyst and intermediate. It can participate in hydrogenation, oxidation, substitution and other reactions, and is often used in the construction of C- C bonds and C- N bonds in organic synthesis.

Preparation Method:
Generally, 3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine can be prepared by reacting bromopyridine with a boronic acid pinacol ester. The specific synthesis method can be adjusted in operation according to actual needs.

Safety Information:
3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine safety information needs to be evaluated on a case-by-case basis. As an organic compound, it may have some irritation and toxicity. During handling and storage, care should be taken to avoid contact with skin, eyes and inhalation of its vapors. It is recommended to use under special laboratory conditions and strictly follow the relevant safety procedures. If necessary, reasonable treatment and disposal shall be carried out in accordance with local laws and regulations. For specific safety information, it is recommended to refer to the relevant safety data and safety data sheets provided by the chemical supplier.

Last Update：2024-04-10 22:29:15