5-Bromo-4-(trifluoromethyl)pyridin-2-ol, 5-Bromo-4-(trifluoromethyl)pyridin-2(1H)-one
5-Bromo-4-trifluoromethyl-pyridin-2-ol
CAS: 109919-32-6
Molecular Formula: C6H3BrF3NO
5-Bromo-4-(trifluoromethyl)pyridin-2-ol, 5-Bromo-4-(trifluoromethyl)pyridin-2(1H)-one - Names and Identifiers
5-Bromo-4-(trifluoromethyl)pyridin-2-ol, 5-Bromo-4-(trifluoromethyl)pyridin-2(1H)-one - Physico-chemical Properties
| Molecular Formula | C6H3BrF3NO |
| Molar Mass | 241.99 |
| Density | 1.876±0.06 g/cm3(Predicted) |
| Boling Point | 226.7±40.0 °C(Predicted) |
| pKa | 8.71±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Irritant |
| MDL | MFCD11227189 |
5-Bromo-4-(trifluoromethyl)pyridin-2-ol, 5-Bromo-4-(trifluoromethyl)pyridin-2(1H)-one - Risk and Safety
| Hazard Class | IRRITANT |
5-Bromo-4-(trifluoromethyl)pyridin-2-ol, 5-Bromo-4-(trifluoromethyl)pyridin-2(1H)-one - Introduction
2-Hydroxy-5-bromo-4-trifluoromethylpyridine is an organic compound with the chemical formula C6H3BrF3NO. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
2-hydroxy-5-bromo-4-trifluoromethylpyridine is a colorless to slightly yellow crystalline powder with a high melting point and good solubility. It is slightly soluble in water and easily soluble in common organic solvents such as alcohols and ketones.
Use:
2-hydroxy-5-bromo-4-trifluoromethylpyridine is a reagent widely used in organic synthesis, which is commonly used in the synthesis of pyridine compounds and the construction of other organic frameworks. It can also be used as an intermediate in the field of pesticides and pharmaceuticals.
Preparation Method:
The synthesis of 2-hydroxy-5-bromo-4-trifluoromethylpyridine can be carried out by a variety of methods. A common method is to react 3-bromo-2-fluoromethylpyridine with sodium hydroxide under alkaline conditions, and then obtain the target product by reduction of alcohol.
Safety Information:
Good laboratory safety practices should be observed when handling 2-hydroxy-5-bromo-4-trifluoromethylpyridine. It can be irritating and corrosive to the eyes, skin and respiratory tract, and therefore requires the wearing of appropriate protective equipment such as safety glasses, gloves and protective clothing. Care should be taken to avoid inhalation of dust or solutions when handling this compound, which may pose a health hazard. Immediately after any contact, flush the affected area with plenty of clean water and seek medical attention if necessary.
Nature:
2-hydroxy-5-bromo-4-trifluoromethylpyridine is a colorless to slightly yellow crystalline powder with a high melting point and good solubility. It is slightly soluble in water and easily soluble in common organic solvents such as alcohols and ketones.
Use:
2-hydroxy-5-bromo-4-trifluoromethylpyridine is a reagent widely used in organic synthesis, which is commonly used in the synthesis of pyridine compounds and the construction of other organic frameworks. It can also be used as an intermediate in the field of pesticides and pharmaceuticals.
Preparation Method:
The synthesis of 2-hydroxy-5-bromo-4-trifluoromethylpyridine can be carried out by a variety of methods. A common method is to react 3-bromo-2-fluoromethylpyridine with sodium hydroxide under alkaline conditions, and then obtain the target product by reduction of alcohol.
Safety Information:
Good laboratory safety practices should be observed when handling 2-hydroxy-5-bromo-4-trifluoromethylpyridine. It can be irritating and corrosive to the eyes, skin and respiratory tract, and therefore requires the wearing of appropriate protective equipment such as safety glasses, gloves and protective clothing. Care should be taken to avoid inhalation of dust or solutions when handling this compound, which may pose a health hazard. Immediately after any contact, flush the affected area with plenty of clean water and seek medical attention if necessary.
Last Update：2024-04-09 20:49:11
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