Name | 5-CHLORO-2'-DEOXYURIDINE |
Synonyms | Chlorodeoxyuridine 5-Chlorodeoxyuridin 5-CHLORODEOXYURIDINE 5-CHLORODESOXYURIDINE 5-CHLORO-2'-DEOXYURIDINE 2'-DEOXY-5-CHLOROURIDINE 5-chloro-2'-deoxy-uridin 5-Chloro-2'-deoxy-D-uridine |
CAS | 50-90-8 |
Molecular Formula | C9H11ClN2O5 |
Molar Mass | 262.65 |
Density | 1.5507 (rough estimate) |
Melting Point | 176-179°C |
Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
Appearance | Solid |
Color | White to Off-White |
pKa | 7.73±0.10(Predicted) |
Storage Condition | -20°C |
Refractive Index | 1.6500 (estimate) |
In vitro study | When 5-Chloro-2’-deoxyuridine (ClDU) is placed into tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In the studies reported here, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect |
Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
WGK Germany | 3 |
RTECS | YU7400000 |
HS Code | 29349990 |
Reference Show more | 1. Pan Wen-Juan, Lin Jia-fu, Wang Xiao-tao, Guo Yi-dong, Yu Yi-Wen, Liu Chao-Lan. Isolation, identification and antibacterial activity of actinomycetes from lakes in Tibet [J]. Biotechnology Bulletin, 2020,36(07):97-103. |
biological activity | 5-Chloro-2 '-deoxyuridine, an analog of thymine, it can be used to study the damaging effect of hypochlorous acid on DNA and DNA precursors. |
category | toxic substances |
toxicity grade | poisoning |
Acute toxicity | intraperitoneal-rat LD50: 2000 mg/kg |
flammability hazard characteristics | flammable; Toxic nitrogen oxides, chloride smoke |
storage and transportation characteristics | low temperature ventilation and drying |
fire extinguishing agent | water, carbon dioxide, foam, sand |