5-Chloropyrazolo[1,5-a]pyrimidine

5-Chloropyrazolo[1,5-a]pyrimidine - Names and Identifiers

Name	5-Chloropyrazolo[1,5-a]pyrimidine
Synonyms	Larotrectinib CPP Impurity WEPRLWNMBTYGGD-UHFFFAOYSA-N 5-Chloropyrazolo[1,5-a]py... 5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE 5-Chloropyrazolo[1,5-a]pyrimidine Pyrazolo[1,5-a]pyriMidine, 5-chloro- 5-chloro-4,5-dihydropyrazolo[1,5-a]pyrimidine
CAS	29274-24-6
InChI	InChI=1/C6H4ClN3/c7-5-2-4-10-6(9-5)1-3-8-10/h1-4H

5-Chloropyrazolo[1,5-a]pyrimidine - Physico-chemical Properties

Molecular Formula	C6H4ClN3
Molar Mass	153.57
Density	1.51±0.1 g/cm3(Predicted)
pKa	-0.49±0.30(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.713

5-Chloropyrazolo[1,5-a]pyrimidine - Risk and Safety

UN IDs	UN2811
Hazard Class	IRRITANT

5-Chloropyrazolo[1,5-a]pyrimidine - Reference Information

Introduction

5-chlorpyrazolo [1,5-a] pyrimidine molecule has two important active units of pyrazole and pyrimidine at the same time. Therefore, these compounds often have good biological activity and have been concerned by pharmaceutical chemists for a long time. Pyrazolo [1,5-a] pyrimidine derivatives have good biological activity and can be used as anti-schistosomiasis agents, anti-tumor drugs, and drugs for the treatment of sleep disorders.

Synthesis method

Using 3-aminopyrazole and ethyl propionate as starting materials, pyrazolo [1,5-a] pyrimidine -5(4H)-one was synthesized, and then the target compound 5-chloropyrazolo [1,5-a] pyrimidine was prepared by chlorination. The synthesis reaction formula is as follows:

Last Update：2024-04-09 15:16:49