5-FORMYLTHIOPHEN-2-BORONIC ACID

5-FORMYLTHIOPHEN-2-BORONIC ACID - Names and Identifiers

Name	5-Formylthiophene-2-boronic acid
Synonyms	5-FORMYLTHIEN-2-YLBORONIC ACID 5-FORMYLTHIENYL-2-BORONIC ACID 5-FORMYLTHIOPHEN-2-BORONIC ACID 5-FORMYLTHIOPHEN-1-BORONIC ACID 5-Formyl-2-thiopheneboronic acid 5-FORMYLTHIOPHENE-2-BORONIC ACID (5-FORMYL-2-THIENYL)BORONIC ACID 5-FORMYL-2-THIOPHENEBORONIC ACID 5-Formylthiophene-2-boronic acid 5-FORMYLTHIOPHEN-2-YLBORONIC ACID (5-formylthiophene-2-yl)boronic acid
CAS	4347-33-5
InChI	InChI=1/C5H5BO3S/c7-3-4-1-2-5(10-4)6(8)9/h1-3,8-9H

5-FORMYLTHIOPHEN-2-BORONIC ACID - Physico-chemical Properties

Molecular Formula	C5H5BO3S
Molar Mass	155.97
Density	1.41±0.1 g/cm3(Predicted)
Melting Point	132-135 °C (lit.)
Boling Point	395.1±52.0 °C(Predicted)
Flash Point	192.7°C
Solubility	soluble in Methanol
Vapor Presure	5.96E-07mmHg at 25°C
Appearance	Yellow to brown crystals
Color	White
pKa	7.23±0.53(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Sensitive	Air Sensitive
Refractive Index	1.573
MDL	MFCD02093666

5-FORMYLTHIOPHEN-2-BORONIC ACID - Risk and Safety

Risk Codes	R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29339900
Hazard Note	Irritant
Hazard Class	IRRITANT, KEEP COLD

5-FORMYLTHIOPHEN-2-BORONIC ACID - Reference Information

introduction

thiophene derivatives are widely used in synthetic pesticides, medicines, chemical reagents, dyes, polymer additives, etc. Antibiotics with thiophene rings have better efficacy than phenyl homologs. 5-aldehyde -2-thiophene boric acid is a thiophene organic substance used as an organic intermediate.

synthesis method

using 5-bromothiophene formaldehyde as raw material, pinacol biborate [B2(pin)2] as boron reagent, K3PO4 · 7H2O as base, in chlorine (2-dicyclohexylphosphinyl -2 ',4',6 '-triisopropyl -1,1'-biphenyl)[2-(2'-amino -1,1'-biphenyl)] palladium (Ⅱ)(Xphos-Pd-G2) and 2-dicyclohexylphospho -2 ',4',6'-triisopropylbiphenyl (Xphos) systems were catalyzed to synthesize 5-aldehyde-2-thiophene borate. The target compound 5-aldehyde -2-thiophene boronic acid was prepared by hydrolysis. The synthesis reaction formula of 5-aldehyde -2-thiophene boric acid is as follows:

Last Update：2024-04-10 22:29:15