5-METHYL-3-PHENYL-4-ISOXAZOLIC ACID

Name	5-methyl-3-phenylisoxazole-4-carboxylic acid
Synonyms	PMI-acid AKOS BBS-00003754 RARECHEM AL BE 0514 TIMTEC-BB SBB010075 5-METHYL-3-PHENYL-4-ISOXAZOLIC ACID 3-phenyl-5-methylisoxazol-4-carbonsaeure 5-methyl-3-phenylisoxazole-4-carboxylic acid 5-METHYL-3-PHENYL-4-ISOXAZOLECARBOXYLIC ACID 5-METHYL-3-PHENYLISOXAZOLE-4-CARBOXYLIC ACID 5-Methyl-3-phenylisoxazole-4-carboxylic acid 5-methyl-3-phenyl-1,2-oxazole-4-carboxylic acid
CAS	1136-45-4
EINECS	214-497-9
InChI	InChI=1/C11H9NO3/c1-7-9(11(13)14)10(12-15-7)8-5-3-2-4-6-8/h2-6H,1H3,(H,13,14)

Molecular Formula	C11H9NO3
Molar Mass	203.19
Density	1.2621 (rough estimate)
Melting Point	192-194°C(lit.)
Boling Point	341.49°C (rough estimate)
Flash Point	174.5°C
Solubility	DMSO (Slightly), Methanol (Very Slightly)
Vapor Presure	5.74E-06mmHg at 25°C
Appearance	White to brown powder or crystal
Color	White to Off-White
BRN	164939
pKa	2.11±0.32(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.4950 (estimate)
MDL	MFCD00003153
Physical and Chemical Properties	The melting point of the product is 192-193 ℃.

Hazard Symbols	Xi - Irritant
Risk Codes	22 - Harmful if swallowed
Safety Description	S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves. S22 - Do not breathe dust.
WGK Germany	3
RTECS	NY2750000
TSCA	Yes
HS Code	2934990002
Hazard Class	IRRITANT

chemical properties	the melting point of this product is 192-193 ℃.
use	used in the production of penicillin sodium.
production method	obtained by hydrolysis after cyclization of benzoxime and ethyl acetoacetate. Stir and mix ethyl acetoacetate with benzoxime ethanol solution, cool to 0 ℃, add sodium hydroxide solution to adjust the pH to 7-8, due to the exothermic reaction, need to cool at about 10 ℃. Then continue to adjust to pH 9-9.5, and react at about 10 ℃ for 4 hours. Add sodium hydroxide solution, heat up and steam out ethanol until 110 ℃, cool, add water, stir and reflux for 3 hours. Acidize with hydrochloric acid to pH = 6, remove the oil layer, add activated carbon to decolorise, filter, and adjust the filtrate to pH = 3.8 with hydrochloric acid. Filtration, washing the filter cake to neutral, vacuum drying, 5-methyl -3-phenyl -4-isoxazole acid.
EPA chemical information	information provided by: ofmpub.epa.gov (external link)

Last Update：2024-04-09 21:54:55

Product Name: 5-Methyl-3-phenyl-1,2-oxazole-4-carboxylic acid Request for quotation
CAS: 1136-45-4
Tel: 18669681830
Email: dechi1118@163.com
Mobile: 18669681830
QQ: 2229890238

Spot supply

Product Name: Oxacillin Impurity 3 (Oxacillin EP Impurity C) Visit Supplier Webpage Request for quotation
CAS: 1136-45-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Product Name: 5-Methyl-3-Phenylisoxazole-4-Carboxylic Acid Visit Supplier Webpage Request for quotation
CAS: 1136-45-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025