5-NITRO-2-THIOPHENECARBOXALDEHYDE

5-NITRO-2-THIOPHENECARBOXALDEHYDE - Names and Identifiers

Name	5-Nitrothiophene-2-carboxaldehyde
Synonyms	AKOS 93853 LABOTEST-BB LT00112375 5-NITROTHIOPHENE-2-CARBALDEHYDE 5-Nitrothiophene-2-carbaldehyde 5-NITRO-2-THIOPHENECARBALDEHYDE 5-Nitrothiophene-2-carboxaldehyde 5-NITROTHIOPHENE-2-CARBOXALDEHYDE 5-NITRO-2-THIOPHENECARBOXALDEHYDE 2-METHYL-6-(DICHLOROMETHYL)PYRIDINE HCL
CAS	4521-33-9
EINECS	224-850-9
InChI	InChI=1/C5H3NO3S/c7-3-4-1-2-5(10-4)6(8)9/h1-3H
InChIKey	CHTSWZNXEKOLPM-UHFFFAOYSA-N

5-NITRO-2-THIOPHENECARBOXALDEHYDE - Physico-chemical Properties

Molecular Formula	C5H3NO3S
Molar Mass	157.15
Density	1.534±0.06 g/cm3(Predicted)
Melting Point	75-77 °C (lit.)
Boling Point	118-120 °C(Press: 3-4 Torr)
Flash Point	133.5°C
Water Solubility	Insoluble in water.
Solubility	acetone: soluble1%, clear, yellow
Vapor Presure	0.00137mmHg at 25°C
Appearance	Solid
Color	Brown
BRN	120540
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Sensitive	Air Sensitive
Refractive Index	1.662
MDL	MFCD00005433

5-NITRO-2-THIOPHENECARBOXALDEHYDE - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
HS Code	29349990

5-NITRO-2-THIOPHENECARBOXALDEHYDE - Reference Information

introduction

thiophene compounds have pharmacological activities such as antibacterial, anti-inflammatory, antiviral and antispasmodic. studying their effects with bovine serum albumin (BSA) is of great significance to the understanding of their pharmacokinetics and the development of new drugs. 5-nitrothiophene-2-formaldehyde is an important intermediate in organic synthesis. It can be used as a pharmaceutical intermediate in the pharmaceutical industry, and can also be used as a raw material to synthesize a series of nitrothiophene Schiff bases.

preparation

0.1 mol5-chloro -2-nitrobenzaldehyde, 0.005mol palladium acetate and 0.006mol 1,10-phenanthroline are dissolved in 20 mL N, N-dimethylformamide, then 0.15mmol hexahydropyridine is added dropwise, stirred at 60 ℃ for 24 hours, poured into water, extracted with ethyl acetate, and recrystallized to obtain 5-nitrothiophene -2-formaldehyde, the yield is 63%.

Last Update：2024-04-09 21:04:16