5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine

5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine - Names and Identifiers

Name	5'-Trityl-2'-deoxy-2,3'-didehydrothymidine
Synonyms	5-O-TRITYL-2',3'-ANHYDROTHYMIDINE 5'-Trityl-2'-deoxy-2,3'-didehydrothymidine 5''-O-TRITYL-2,3''-ANHYDROTHYMIDINE (5-OTT+1) 5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine 5-O-Triphenylmethyl-2-Deoxy-2,3-Didehyrothymidine 5'-o-Triphenylmethyl-2-deoxy-2',3-didehydrothymidine 2,3'-Anhydro-1-(2-deoxy-5-O-trityl-b-D-threo-pentofuranosyl)-thymine 8-methyl-3-[(trityloxy)methyl]-2,3-dihydro-9H-2,5-methanopyrimido[2,1-b][1,5,3]dioxazepin-9-one 2,3-dihydro-8-methyl-3-[(trityloxy)methyl]-2,5-methano-5h,9h-pyrimido[2,1-b][1,5,3]dioxazepin-9-one (2R,3R,5R)-2,3-Dihydro-8-methyl-3-[(triphenylmethoxy)methyl]-2,5-methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one
CAS	25442-42-6
EINECS	607-727-8
InChI	InChI=1/C29H26N2O4/c1-20-18-31-26-17-24(35-28(31)30-27(20)32)25(34-26)19-33-29(21-11-5-2-6-12-21,22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,18,24-26H,17,19H2,1H3

5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine - Physico-chemical Properties

Molecular Formula	C29H26N2O4
Molar Mass	466.53
Density	1.27±0.1 g/cm3(Predicted)
Melting Point	229-230 °C
Boling Point	595.7±60.0 °C(Predicted)
Flash Point	314.1°C
Solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
Vapor Presure	3.7E-14mmHg at 25°C
Appearance	Solid
Color	White to Pale Yellow
pKa	-3.52±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.651

5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine - Introduction

5 '-Trityl-2'-deoxy-2,3 '-dihydroxymidine (5'-Trityl-2 '-deoxy-2,3'-dihydroxymidine) is an organic compound. It is derived from thymidine (thymidine), in which the 3 'and 2' hydrogen atoms are removed, and the 5 'position is attached with a phenyl group.

The molecular formula of 5 '-Trityl-2'-deoxy-2,3 '-didehydrothymidine is C28H23N2O2, and the relative molecular mass is 421.50g/mol. It appears as orange to yellow crystals and is soluble in organic solvents such as dimethyl sulfoxide and methylene chloride.

The compound is mainly used in the field of organic synthesis as an intermediate in the process of DNA synthesis. Its phenyl group can protect a specific position in the thymidine molecule for modification in the reaction. For example, it can be used to synthesize nucleic acid fluorescent probes with specific functions.

The preparation of 5 '-Trityl-2'-deoxy-2,3 '-didehydrothymidine usually uses chemical synthesis methods. First, Thymidine is used as the starting material, and after a series of chemical reactions and the addition and removal of protective groups, finally, the target product is obtained.

Last Update：2024-04-10 22:29:15