5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)-6-quinoxalinamine tartrate
brimonidine d-tartrate
CAS: 70359-46-5
Molecular Formula: C15H16BrN5O6
5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)-6-quinoxalinamine tartrate - Names and Identifiers
| Name | brimonidine d-tartrate |
| Synonyms | UK 14,304 TARTRATE BRIMONIDINE TARTATE Brimonidine tartrate Brimonidinne tartrate brimonidine d-tartrate BRIMONIDINE D-TARTRATE Brimonidine-L-Tartrate Brimonidine Tartrate(Alphagan) 5-BROMO-6-(2-IMIDAZOLIN-2-YLAMINO)QUINOXALINE TARTRATE 5-BROMO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-QUINOXALINAMINE TARTRATE 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)-6-quinoxalinamine tartrate 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine 2,3-dihydroxybutanedioate (salt) |
| CAS | 70359-46-5 |
| EINECS | 629-848-5 |
| InChI | InChI=1/C11H10BrN5.C4H6O6/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8;5-1(3(7)8)2(6)4(9)10/h1-4H,5-6H2,(H2,15,16,17);1-2,5-6H,(H,7,8)(H,9,10) |
| InChIKey | QZHBYNSSDLTCRG-WUUYCOTASA-N |
5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)-6-quinoxalinamine tartrate - Physico-chemical Properties
| Molecular Formula | C15H16BrN5O6 |
| Molar Mass | 442.22 |
| Melting Point | 207-208°C (dec.) |
| Boling Point | 432.6°C at 760 mmHg |
| Flash Point | 215.4°C |
| Vapor Presure | 1.1E-07mmHg at 25°C |
| Appearance | Solid |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Physical and Chemical Properties | Appearance Off-white to faint yellow powder |
| In vitro study | Brimonidine reduced the progressive loss of ganglion cells by 26% and 15% at doses of 0.5 mg/kg and 1 mg/kg, respectively. Brimonidine prevents further loss of ganglion cells after 10 days of increased intraocular pressure. In the hypertensive retina of the attenuated eye, Brimonidine increases the immune response to GFAP. Brimonidine, but not timolol, was used when intraocular pressure (IOP) was elevated to significantly protect retinal ganglion cells and prevent further cell loss. Brimonidine injection into the eyes of SD rats increased the number of BDNF-positive retinal ganglion cells from 55 to 166 percent. 0.5% Brimonidine,1 drop before, after, or before and after 360-degree argon laser trabeculoplasty significantly reduced the incidence of intraocular pressure. |
| In vivo study | In adult rats, Brimonidine(1 mg/kg) significantly protected retinal ganglion cell death induced by ocular hypertension. Brimonidine(0.0001%) caused a loss of about 37% of retinal ganglion cells (RGC) and had no significant neuroprotective effect in adult Sprague-Dawley rats. Brimonidine(0.001 or 0.01) caused retinal ganglion cell (RGC) survival of 76 or 90%, respectively, in ischemic adult SD rats, 0.1%Brimonidine completely prevented retinal ganglion cell (RGC) death. |
5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)-6-quinoxalinamine tartrate - Risk and Safety
| UN IDs | UN 2811 6.1 / PGIII |
| HS Code | 29332900 |
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Product Name: 5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)-6-Quinoxalinamine Tartrate Visit Supplier Webpage Request for quotationCAS: 70359-46-5
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Multiple Specifications
Product Name: Brimonidine L-Tartrate Request for quotationCAS: 70359-46-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: 5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)-6-Quinoxalinamine Tartrate Visit Supplier Webpage Request for quotationCAS: 70359-46-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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