5-fluoro-2-methoxyphenylmagnesium bromide
5-fluoro-2-methoxyphenylmagnesium bromide
CAS: 188132-02-7
Molecular Formula: C7H6BrFMgO
5-fluoro-2-methoxyphenylmagnesium bromide - Names and Identifiers
5-fluoro-2-methoxyphenylmagnesium bromide - Physico-chemical Properties
| Molecular Formula | C7H6BrFMgO |
| Molar Mass | 229.33 |
| Density | 0.948g/mLat 25°C |
| Boling Point | 65°C |
| Flash Point | 1°F |
| Vapor Presure | 3.51mmHg at 25°C |
| Appearance | Solution |
| Color | Clear yellow to brown |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | WGK Germany:1 |
5-fluoro-2-methoxyphenylmagnesium bromide - Risk and Safety
| Risk Codes | R11 - Highly Flammable R14/15 - R19 - May form explosive peroxides R34 - Causes burns R40 - Limited evidence of a carcinogenic effect R36/37 - Irritating to eyes and respiratory system. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S43 - In case of fire use ... (there follows the type of fire-fighting equipment to be used.) S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2924 3/PG 2 |
| WGK Germany | 1 |
| HS Code | 29310099 |
5-fluoro-2-methoxyphenylmagnesium bromide - Reference Information
| preparation method | The Grignard reagent 5-fluoro-2-methylphenylmagnesium bromide was generated in a single CSTR: A slurry of magnesium (227g,9.4mol) was activated in MeTHF(1L) to prepare mint1 Grignard reagent (1207G), which occurred immediately after the stirring was activated. To compound 1(23%(w/w)) MeTHF was added to the CSTR at a rate of 34.5mL/min, the steady state τ was 0.5 hours, and the vessel temperature was 40 °c. The reaction solution exits through the dip tube and is used as solid magnesium in a Isolation CSTR, then the solution is collected in A accumulation vessel (34.5mL/min) at 1-fold rate. This operation was run as a start/stop operation for more than 5 days with a total processing time of 32 hours. Rest overnight. The yield of 5-fluoro-2-methylphenylmagnesium bromide was 1.68 (69.6 mol). Overall, there was a total of 30 liters of 5-fluoro-2-methylphenylmagnesium bromide Grignard reagent (conversion 97%, yield 95%). |
| Application | 5-fluoro-2-methylphenylmagnesium bromide can be used as a pharmaceutical synthesis intermediate. |
Last Update：2024-04-09 20:52:54
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