566914-00-9

566914-00-9 - Names and Identifiers

Name	N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-benzenepropanamide
Synonyms	TLR1 IL-1R Antagonist IL-1R antagonist(TLR1) Benzenepropanamide, N-[(1S)-2-methyl-1-(pyrrolidinylcarbonyl)propyl]- N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-benzenepropanamide Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]- (S)-N-(3-Methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-3-phenylpropanamide N-[(2S)-3-Methyl-1-oxo-1-(1-pyrrolidinyl)-2-butanyl]-3-phenylpropanamide
CAS	566914-00-9

566914-00-9 - Physico-chemical Properties

Molecular Formula	C18H26N2O2
Molar Mass	302.41
Solubility	Soluble in DMSO
Storage Condition	-20℃
Use	TLR1 (compound 4a) is a low molecular weight, cell penetration Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimetic. TLR1 inhibits IL-1 receptor-mediated responses.
In vitro study	TLR1 inhibits IL-1β-induced phosphorylation of the mitogen-activated protein kinase p38 in EL4 thymoma cells and in freshly isolated murine lymphocytes in a concentration-dependent manner.
In vivo study	TLR1 interferes with the interactions between mouse MyD88 and IL-1RI at the TIR domains. TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.).

566914-00-9 - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	3.307 ml	16.534 ml	33.068 ml
5 mM	0.661 ml	3.307 ml	6.614 ml
10 mM	0.331 ml	1.653 ml	3.307 ml
5 mM	0.066 ml	0.331 ml	0.661 ml

Last Update：2024-01-02 23:10:35

566914-00-9 - Reference Information

biological activity

TLR1 (compound 4a) is a kind of low molecular weight, cells penetrate Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimetic. TLR1 inhibits IL-1 of receptor-mediated responses.

Last Update：2024-04-09 21:01:54