57749-43-6 - Names and Identifiers
Name | EQUISETIN
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Synonyms | LS-64262 EQUISETIN (3E,5S)-3-[[(1S,2R,4aS,6R,8aR)-1,6-dimethyl-2-[(E)-prop-1-enyl]-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]-hydroxymethylidene]-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione 2,4-Pyrrolidinedione, 5-(hydroxymethyl)-3-[hydroxy[(1S,2R,4aS,6R,8aR)-1,2,4a,5,6,7,8,8a-octahydro-1,6-dimethyl-2-(1E)-1-propen-1-yl-1-naphthalenyl]methylene]-1-methyl-, (3E,5S)-
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CAS | 57749-43-6
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57749-43-6 - Physico-chemical Properties
Molecular Formula | C22H31NO4
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Molar Mass | 373.49 |
Density | 1.180±0.06 g/cm3(Predicted) |
Melting Point | 117-118 °C |
Boling Point | 556.0±50.0 °C(Predicted) |
Solubility | Acetone (Slightly), DMSO (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | Pale Beige to Light Brown |
pKa | 4.50±1.00(Predicted) |
Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
Stability | Hygroscopic |
Physical and Chemical Properties | The bioactive Equisetin is N-methylserine-derived acyltramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537. As a natural product containing quadruplets, it has antibiotic and cytotoxic activities. It can inhibit the growth of gram-positive bacteria and HIV-1 integrase activity, but has no activity against gram-negative bacteria. Equisetin, a quorum sensing inhibitor (QSI) that attenuates QS-regulated toxic phenotypes in Pseudomonas aeruginosa without affecting bacterial growth, is a major compound in the study of Pseudomonas aeruginosa infection. |
57749-43-6 - Risk and Safety
57749-43-6 - Introduction
EQUISETIN, also known as EQUISETIN, is a natural product that belongs to the class of hemicyclin compounds in the class Bacillus. The following is an introduction to the nature, use, formulation and safety information of EQUISETIN:
1. Nature:
EQUISETIN is a yellow to orange crystalline powder with a distinctive fragrance. It is almost insoluble in water and has good solubility in alcohols and organic solvents. EQUISETIN has antibacterial and antitumor activity, and has an inhibitory effect on some bacteria and fungi.
2. Use:
EQUISETIN is widely studied and used in the field of medicine. It has antibacterial and antitumor activities and can be used to develop new antibiotics and anticancer drugs. In addition, EQUISETIN is also used as a biological pesticide in the agricultural field to replace chemical pesticides, thereby improving the disease resistance of crops.
3. Preparation method:
EQUISETIN can be obtained by fermentation of microbial Equisetin-producing fungus or synthetic methods. The fermentation process involves culturing an EQUISETIN-producing microorganism and obtaining the product by extraction and purification. The synthetic method is to synthesize the EQUISETIN molecule by chemical synthesis.
4. Safety Information:
EQUISETIN is a natural product, but it is still necessary to pay attention to safety during use or research. EQUISETIN has a certain toxicity, should follow the relevant laboratory safety procedures. Wear appropriate personal protective equipment to avoid inhalation or contact with EQUISETIN during use or handling. At the same time, the storage of EQUISETIN also needs to avoid contact with oxygen and moisture to prevent its loss of activity.
Last Update:2024-04-09 21:11:58