5α-Pregnane-3β,6α-diol-20-one
5α-Pregnane-3β,6α-diol-20-one
CAS: 21853-11-2
Molecular Formula: C21H34O3
5α-Pregnane-3β,6α-diol-20-one - Names and Identifiers
5α-Pregnane-3β,6α-diol-20-one - Physico-chemical Properties
| Molecular Formula | C21H34O3 |
| Molar Mass | 334.49 |
| Density | 1.117±0.06 g/cm3(Predicted) |
| Melting Point | 202-203 °C |
| Boling Point | 469.7±30.0 °C(Predicted) |
| pKa | 14.72±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Use | 5α-Pregnane-3β,6α-diol-20-one is a mitogenic progestone metabolite that is produced in androgen-responsive prostaglandin cancer cells when serum is deficient. |
| In vitro study | Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity. |
5α-Pregnane-3β,6α-diol-20-one - Introduction
5α-Pregnane-3β,6α-diol-20-one (abbreviated as Pregnane-3β,6α-diol-20-one) is a steroid compound with the following properties:
Physical Properties:
-chemical formula: C21H32O2
-Molecular weight: 316.48g/mol
-Appearance: White crystalline powder
-Melting Point: 141-143 ° C
-Solubility: Soluble in chloroform, alcohol and ethyl acetate, slightly soluble in ether and petroleum ether, almost insoluble in water.
Use:
Pregnane-3β,6α-diol-20-one is mainly used in the field of medicine, as an active ingredient to participate in the synthesis and research of some drugs. It is commonly used for synthetic hormones and other steroid drugs such as cortisol and sex hormones. In addition, it can be used for in vivo and in vitro biochemical studies, as well as for assessing its effects on biological systems.
Preparation Method:
There are many preparation methods for Pregnane-3β,6α-diol-20-one. One of the commonly used methods is to synthesize by extracting from plants or reacting natural hormones. The synthetic method includes different chemical reaction steps, such as hydrogenation, acylation, bromination, etc.
Safety Information:
The safety data on Pregnane-3β,6α-diol-20-one is limited, so caution is required when using and handling. The compound may be toxic to humans, so appropriate safety measures must be taken, such as wearing protective gloves and goggles, keeping the operating area well ventilated, and avoid direct skin contact or inhalation of its dust. In case of contact or inhalation, rinse immediately with water and seek medical help.
Physical Properties:
-chemical formula: C21H32O2
-Molecular weight: 316.48g/mol
-Appearance: White crystalline powder
-Melting Point: 141-143 ° C
-Solubility: Soluble in chloroform, alcohol and ethyl acetate, slightly soluble in ether and petroleum ether, almost insoluble in water.
Use:
Pregnane-3β,6α-diol-20-one is mainly used in the field of medicine, as an active ingredient to participate in the synthesis and research of some drugs. It is commonly used for synthetic hormones and other steroid drugs such as cortisol and sex hormones. In addition, it can be used for in vivo and in vitro biochemical studies, as well as for assessing its effects on biological systems.
Preparation Method:
There are many preparation methods for Pregnane-3β,6α-diol-20-one. One of the commonly used methods is to synthesize by extracting from plants or reacting natural hormones. The synthetic method includes different chemical reaction steps, such as hydrogenation, acylation, bromination, etc.
Safety Information:
The safety data on Pregnane-3β,6α-diol-20-one is limited, so caution is required when using and handling. The compound may be toxic to humans, so appropriate safety measures must be taken, such as wearing protective gloves and goggles, keeping the operating area well ventilated, and avoid direct skin contact or inhalation of its dust. In case of contact or inhalation, rinse immediately with water and seek medical help.
Last Update：2024-04-09 21:54:55
