6-(trifluoromethoxy)quinolin-4-ol

6-(trifluoromethoxy)quinolin-4-ol - Names and Identifiers

Name	4-Hydroxy-6-(trifluoromethoxy)quinoline
Synonyms	6-Trifluoromethoxyquinolin-4-ol 6-(TRIFLUOROMETHOXY)-4-QUINOLINOL 6-(trifluoromethoxy)quinolin-4-ol 4-Quinolinol, 6-(trifluoromethoxy)- 4-HYDROXY-6-(TRIFLUOROMETHOXY)QUINOLINE 4-Hydroxy-6-(trifluoromethoxy)quinoline
CAS	175203-87-9
InChI	InChI=1/C10H6F3NO2/c11-10(12,13)16-6-1-2-8-7(5-6)9(15)3-4-14-8/h1-5H,(H,14,15)

6-(trifluoromethoxy)quinolin-4-ol - Physico-chemical Properties

Molecular Formula	C10H6F3NO2
Molar Mass	229.16
Density	1.473g/cm³
Melting Point	233-236°C
Boling Point	301.735°C at 760 mmHg
Flash Point	136.285°C
Vapor Presure	0.001mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.572

6-(trifluoromethoxy)quinolin-4-ol - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

6-(trifluoromethoxy)quinolin-4-ol - Introduction

4-Hydroxy-6-(trifluoromethoxy)quinoline, also known as 6-fluoro-7-fluoromethoxyquinoline or OTf-6, has important applications and properties in the field of chemistry.

Nature:
4-Hydroxy-6-(trifluoromethoxy)quinoline is a colorless to pale yellow solid with high stability, solubility and reactivity. It is an organic compound with the molecular formula C11H8F3NO2 and a molecular weight of 251.18g/mol.

Use:
1. 4-Hydroxy-6-(trifluoromethoxy)quinoline is an important transition metal ligand, which can be used in the synthesis of catalysts and organic chemical reactions.
2. It can be used as an additive to the solvent to enhance the stability of the solution and the efficiency of the catalytic reaction process.
3. 4-Hydroxy-6-(trifluoromethoxy)quinoline can also be used for fluorination reactions and nucleophilic substitution reactions in organic synthesis.

Method:
Generally, 4-Hydroxy-6-(trifluoromethoxy)quinoline can be prepared by the reaction of quinoline and trifluoromethyl alcohol. First, quinoline and trifluoromethyl alcohol are reacted by heating under suitable conditions to produce 4-Hydroxy-6-(trifluoromethoxy)quinoline.

Safety Information:
When using or storing 4-Hydroxy-6-(trifluoromethoxy)quinoline, some basic safety measures should be observed:
1. 4-Hydroxy-6-(trifluoromethoxy)quinoline should be kept dry and sealed to avoid contact with moisture and air.
2. Wear appropriate protective gloves, eye and respiratory protective equipment during operation.
3. Avoid contact with skin and eyes. If contact occurs, rinse immediately with plenty of water and seek medical help.
4. When disposing of waste, it should be properly disposed of in accordance with local regulations.

Last Update：2024-04-10 22:29:15