6-CHLORO-3-NITRO-2-METHYLPYRIDINE

Name	2-Chloro-6-methyl-5-nitropyridine
Synonyms	TIMTEC-BB SBB003832 TIMTEC-BB SBB003830 2-CHLORO-5-NITRO-6-PICOLINE 6-CHLORO-3-NITRO-2-PICOLINE 2-CHLORO-5-NITRO-6-METHYLPYRIDINE 6-Chloro-2-methyl-3-nitropyridine 2-Chloro-6-methyl-5-nitropyridine 6-CHLORO-3-NITRO-2-METHYLPYRIDINE 2-CHLORO-6-METHYL-3-NITROPYRIDINE 2-CHLORO-6-METHYL-5-NITROPYRIDINE 6-Chloro-2-methyl-3-nitro-pyridine
CAS	22280-60-0
InChI	InChI=1/C6H5ClN2O2/c1-4-2-3-5(9(10)11)6(7)8-4/h2-3H,1H3
InChIKey	GHSRMSJVYMITDX-UHFFFAOYSA-N

Molecular Formula	C6H5ClN2O2
Molar Mass	172.57
Density	1.5610 (rough estimate)
Melting Point	54-58 °C
Boling Point	200°C (rough estimate)
Flash Point	124.2°C
Vapor Presure	0.00597mmHg at 25°C
Appearance	Powder
Color	Light beige to brown
pKa	-3.26±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.5500 (estimate)

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R22 - Harmful if swallowed
Safety Description	S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
HS Code	29333990
Hazard Note	Harmful
Hazard Class	IRRITANT

introduction	6-chloro-2-methyl-3-nitropyridine has a melting point of 54 to 58 degrees, a boiling point of 281.7±35.0 degrees (at one atmosphere), a density of 1.4, and a light beige to brown solid powder under normal temperature and pressure, which can be used as an organic synthesis intermediate.
Use	6-chloro-2-methyl-3-nitropyridine can be used as an intermediate in pharmaceutical chemistry and organic synthesis, and the nitro group in its structure can be Under appropriate conditions, it is reduced to amino group (the reduction system is more iron powder plus acetic acid), because the reaction is carried out under acidic conditions, after the reaction is over, the pH of the reaction needs to be adjusted. In addition, because of the electron-deficient nature of the pyridine ring, the chlorine atoms on the pyridine ring can be attacked by nucleophiles under certain conditions to obtain dechlorinated functional products.
Synthesis method	For the synthesis of 6-chloro-2-methyl-3-nitropyridine, the conventional synthesis method is from its precursor 2-Hydroxy-6-methyl-5-nitropyridine starts and undergoes deoxychlorination reaction under the action of phosphorus oxychloride and phosphine pentachloride to obtain the target product. It is worth noting that the reaction needs to be carried out at a high temperature to better ensure the reaction efficiency and yield.

Last Update：2024-04-09 21:11:58

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