6-Chlorpyridazin-3-carboxamid

6-Chlorpyridazin-3-carboxamid - Names and Identifiers

Name	6-Chloropyridazine-3-carboxamide
Synonyms	CML-035 6-Chlorpyridazin-3-carboxamid 6-Chloro-3-pyridazinecarboxamide 6-Chloropyridazine-3-carboxamide 3-Chloro-pyridazine-6-carboxamide 3-pyridazinecarboxamide, 6-chloro- 3-PyridazinecarboxaMide, 6-chloro- 3-Carbamoyl-6-chloropyridazine, 3-(Aminocarbonyl)-6-chloro-1,2-diazine
CAS	66346-83-6
InChI	InChI=1/C5H4ClN3O/c6-4-2-1-3(5(7)10)8-9-4/h1-2H,(H2,7,10)

6-Chlorpyridazin-3-carboxamid - Physico-chemical Properties

Molecular Formula	C5H4ClN3O
Molar Mass	157.56
Density	1.479g/cm³
Boling Point	424.641°C at 760 mmHg
Flash Point	210.616°C
Vapor Presure	0mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.596

6-Chlorpyridazin-3-carboxamid - Risk and Safety

Hazard Symbols

Xi - Irritant

6-Chlorpyridazin-3-carboxamid - Reference Information

preparation

6-chlorpyridazine -3-formamide was prepared by one-step reaction with ammonia water as the starting material; or use 6-chlorpyridine-3-formic acid to react with oxalyl chloride to prepare 6-chlorpyridine-3-formyl chloride and then react with ammonia to prepare the target compound to prepare 6-chlorpyridine-3-formamide. The synthesis reaction formula of 6-chlorpyridine-3-formamide is as follows: Experimental operation: Weit 6-chlorpyridine-3-formate methyl ester and add it to the high-pressure reaction kettle, add ethanol in turn, 25% ammonia water, and replace the air in the kettle with nitrogen for 3 times, stir and raise the temperature to 100 ℃ for 6 hours, cool down to 5 ℃ at the end of the reaction, stir for 1 hour, crystallize, filter, wash with water, vacuum dry at 50 ℃, 6-chlorpyridazine-3-formamide was obtained.

Last Update：2024-04-09 21:01:54