6-Methyl-2-pyridylzinc bromide
6-Methyl-2-pyridylzinc bromide
CAS: 308795-98-4
Molecular Formula: C6H6BrNZn
6-Methyl-2-pyridylzinc bromide - Names and Identifiers
6-Methyl-2-pyridylzinc bromide - Physico-chemical Properties
| Molecular Formula | C6H6BrNZn |
| Molar Mass | 237.41 |
| Density | 0.996g/mLat 25°C |
| Flash Point | 1°F |
| Appearance | Liquid |
| Color | Yellow to brown to black |
| Exposure Limit | ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)OSHA: TWA 200 ppm(590 mg/m3)NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) |
| Storage Condition | 2-8°C |
| Sensitive | Air Sensitive |
6-Methyl-2-pyridylzinc bromide - Risk and Safety
| Risk Codes | R19 - May form explosive peroxides R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin. R40 - Limited evidence of a carcinogenic effect R36/37 - Irritating to eyes and respiratory system. R14 - Reacts violently with water R11 - Highly Flammable |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 3399 4.3/PG 2 |
| WGK Germany | 1 |
| Hazard Class | 4.3 |
6-Methyl-2-pyridylzinc bromide - Introduction
The 6-Methyl-2-pyridylzinc bromide is an organometallic compound with the chemical formula C6H6BrN2Zn. It is a white crystal, soluble in non-polar organic solvents (such as ether, dichloromethane), stable in air. The following is a detailed description of the nature, use, preparation and safety information of the 6-Methyl-2-pyridylzinc bromide:
Nature:
1. Appearance: white crystal
2. Melting point: 94-96°C
3. Solubility: Soluble in non-polar organic solvents
4. Stability: relatively stable at room temperature, but should avoid long-term contact with moisture and oxygen in the air
Use:
6-Methyl-2-pyridylzinc bromide is mainly used for cross-coupling reaction (cross-coupling reaction) in organic synthesis reaction. It can be used as a substrate or reagent to participate in phenyl, allylation, propargylation and other reactions. It is often used to construct complex molecular structures in organic synthesis, including the synthesis of drugs, pesticides and organic electronic materials.
Preparation Method:
6-Methyl-2-pyridylzinc bromide are generally obtained by reacting zinc hexachloride with 2-bromomethylpyridine. Firstly, 6-methyl-2-pyridine and zinc powder were placed in a reaction flask, and zinc hexachloride was added slowly. After the reaction, the product 6-Methyl-2-pyridylzinc bromide was obtained.
Safety Information:
1. 6-Methyl-2-pyridylzinc bromide has certain toxicity and irritation to human body, and direct contact with skin, eyes and respiratory tract should be avoided.
2. use should wear protective glasses, gloves and masks to prevent inhalation of gas or skin contact.
3. It should be operated under well-ventilated laboratory conditions to avoid inhaling its gas or solution vapor.
4. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
5. 6-Methyl-2-pyridylzinc bromide should be stored in a dry, low-temperature place, away from oxidants, heat sources and open flames.
Nature:
1. Appearance: white crystal
2. Melting point: 94-96°C
3. Solubility: Soluble in non-polar organic solvents
4. Stability: relatively stable at room temperature, but should avoid long-term contact with moisture and oxygen in the air
Use:
6-Methyl-2-pyridylzinc bromide is mainly used for cross-coupling reaction (cross-coupling reaction) in organic synthesis reaction. It can be used as a substrate or reagent to participate in phenyl, allylation, propargylation and other reactions. It is often used to construct complex molecular structures in organic synthesis, including the synthesis of drugs, pesticides and organic electronic materials.
Preparation Method:
6-Methyl-2-pyridylzinc bromide are generally obtained by reacting zinc hexachloride with 2-bromomethylpyridine. Firstly, 6-methyl-2-pyridine and zinc powder were placed in a reaction flask, and zinc hexachloride was added slowly. After the reaction, the product 6-Methyl-2-pyridylzinc bromide was obtained.
Safety Information:
1. 6-Methyl-2-pyridylzinc bromide has certain toxicity and irritation to human body, and direct contact with skin, eyes and respiratory tract should be avoided.
2. use should wear protective glasses, gloves and masks to prevent inhalation of gas or skin contact.
3. It should be operated under well-ventilated laboratory conditions to avoid inhaling its gas or solution vapor.
4. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
5. 6-Methyl-2-pyridylzinc bromide should be stored in a dry, low-temperature place, away from oxidants, heat sources and open flames.
Last Update：2024-04-09 15:18:01
