6-methylpyridin-3-ol
3-Hydroxy-6-methylpyridine
CAS: 1121-78-4
Molecular Formula: C6H7NO
6-methylpyridin-3-ol - Names and Identifiers
| Name | 3-Hydroxy-6-methylpyridine |
| Synonyms | 6-methyl-3-pyridino 6-METHYL-3-PYRIDINOL 6-methylpyridin-3-ol 6-Methyl-3-pyridinol 6-METHYLPYRIDIN-3-OL 5-HYDROXY-2-PICOLINE 3-Pyridinol, 6-methyl- 6-Methylpyridin-3-ol 3-HYDROXY-6-METHYLPYRIDINE 5-Hydroxy-2-methylpyridine 5-HYDROXY-2-METHYLPYRIDINE 3-Hydroxy-6-methylpyridine 6-METHYL-3-HYDROXYPYRIDINE 2-Methyl-5-hydroxypyridine 2-METHYL-5-HYDROXY PYRIDINE |
| CAS | 1121-78-4 |
| EINECS | 214-337-8 |
| InChI | InChI=1/C6H7NO/c1-5-2-3-6(8)4-7-5/h2-4,8H,1H3 |
| InChIKey | DHLUJPLHLZJUBW-UHFFFAOYSA-N |
6-methylpyridin-3-ol - Physico-chemical Properties
| Molecular Formula | C6H7NO |
| Molar Mass | 109.13 |
| Density | 1.1143 (rough estimate) |
| Melting Point | 168-170°C(lit.) |
| Boling Point | 204.59°C (rough estimate) |
| Flash Point | 132.7°C |
| Solubility | dichloromethane: soluble |
| Vapor Presure | 0.000846mmHg at 25°C |
| Appearance | Pale yellow solid |
| Color | Beige to light tan |
| BRN | 107077 |
| pKa | 9.49±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.5040 (estimate) |
| MDL | MFCD00006339 |
6-methylpyridin-3-ol - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R40 - Limited evidence of a carcinogenic effect R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S22 - Do not breathe dust. |
| WGK Germany | 3 |
| RTECS | UU7714900 |
| HS Code | 29333990 |
6-methylpyridin-3-ol - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| introduction | the melting point of 3-hydroxy -6-methylpyridine is 168-170 c (lit.), which is an important industrial raw material and is widely used in medicine, pesticide, dye and other industries. Because pyridine ring has biological activity and has irreplaceable role of other groups or functional groups in the synthesis of drugs, it is a hot field in medical research. |
| Uses | 3-hydroxy-6-methylpyridine can be used as a chemical intermediate for organic synthesis and experimental research. 3-Hydroxy-6-methylpyridine is also an important organic chemical raw material, which can be used to make spices, and it is also an intermediate for the synthesis of various drugs in the pharmaceutical industry. The large π conjugate of pyridine ring can promote photoluminescence performance and conductivity. |
| Synthesis method | Add a solution of K2CO3(0.552g, 4 mmol) in 30 ml of methanol to polysubstituted -5-(trimethylsilyl) pento-1-ene-4-yne-3-ol. Stir the mixture at room temperature. The reaction mixture was filtered through a silica gel short plug. Concentration filtration. The product 3-hydroxy-6-methylpyridine was obtained by rapid chromatographic purification. |
Last Update：2024-04-09 02:00:06
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